Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population

Table 1

Accuracy and precision results for TLN bioassay.

Accuracy and precision (n = 5, three days)		LLOQ (4 nMol/L)	LQC (12 nMol/L)	MQC (500 nMol/L)	HQC (800 nMol/L)
1st day, intraday	Average recovery	80.0	109.89	92.85	96.28
	Bias (mean, n = 5)	−20.0	9.89	−7.15	−3.72
	S.D.	13.71	7.65	4.58	4.05
	% R.S.D	17.14	6.96	4.92	4.21
2nd day, intraday	Average recovery	80.76	103.61	99.80	99.40
	Bias (mean, n = 5)	−19.24	3.61	−0.20	−0.60
	S.D.	11.09	3.85	2.16	1.03
	% R.S.D	13.74	3.72	2.16	1.04
3rd day, intraday	Average recovery	81.32	102.79	97.74	97.20
	Bias (mean, n = 5)	−18.68	2.79	−2.26	−2.80
	S.D.	9.80	5.57	2.17	3.10
	% R.S.D	12.05	5.42	2.22	3.19
Interday	Average recovery	80.56	105.56	96.80	97.63
	Bias (mean, n = 5)	−19.44	5.56	−3.20	−2.37
	S.D.	12.38	6.96	4.31	3.28
	% R.S.D	15.36	6.59	4.45	3.36