Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

<div>MRM chromatograms of diclofenac, tolbutamide, warfarin and chlorzoxazone (IS) from rat plasma. (a) Blank rat plasma; (b) Blank plasma samples spiked with standard substance (LLOQ) and IS; (c) Real plasma samples obtained from a rat following administration of 2 mg/kg diclofenac, 30 mg/kg tolbutamide, and 2 mg/kg warfarin.</div>

Journal of Analytical Methods in Chemistry

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Figure 2: Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions 

Figure 2 | Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions 