Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

Table 1

The mass scan method parameters of diclofenac and chlorzoxazone (internal standard, IS).

Compounds	Q1 (m/z)	Q3 (m/z)	Dwell time (msec)	Cone (V)	Collision energy
Diclofenac	295.67	216.23^a	0.044	20	20
		177.91^b	0.044	20	30
Chlorzoxazone	167.78	131.88^a	0.044	20	18
		75.85^b	0.044	20	24

^aQuantitative analysis. ^bQualitative analysis.