Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

Table 2

Mass scan method parameters of tolbutamide, warfarin, and chlorzoxazone (internal standard, IS).

Compounds	Q1 (m/z)	Q3 (m/z)	DP (V)	EP (V)	CE (V)	CXP (V)
Tolbutamide	269.2	170.0	−55	−10	−26	−17
Warfarin	307.1	250.0	−30	−10	−31	−17
Chlorzoxazone	168.0	132.0	−90	−10	−28	−17

DP: declustering potential; EP: entrance potential; CE: collision energy; CXP: collision cell exit potential.