Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

Table 6

Pharmacokinetic parameters of diclofenac in the treated group and control group.

Pharmacokinetic parameters	Treated group	Control group
t1/2 (h)	0.87 ± 0.32	1.04 ± 0.37
Tmax (h)	0.12 ± 0.06	0.11 ± 0.08
Cmax (μg/L)	1287.82 ± 454.16	258.66 ± 103.52
AUC0-t	1509.59 ± 304.91	741.98 ± 215.78
AUC0-∞	1509.59 ± 304.91	741.99 ± 215.78
Vd (L/kg)	1.68 ± 0.42	4.66 ± 2.40
CL (L/h/kg)	1.44 ± 0.35	2.98 ± 0.76

Pharmacokinetic parameters were calculated by DAS 3.2.8 software. t1/2: elimination half-life; T_max: the time of peak concentration; C_max: the maximum concentration; AUC0-t, AUC0-∞: area under the plasma concentration-time profiles; V_d: volume of distribution; CL: clearance. compared with the control group.