Research Article
Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions
Table 7
Pharmacokinetic parameters of tolbutamide in the treated group and control group.
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Pharmacokinetic parameters were calculated by DAS 3.2.8 software. t1/2: elimination half-life; Tmax: the time of peak concentration; Cmax: the maximum concentration; AUC0-t, AUC0-∞: area under the plasma concentration-time profiles; Vd: volume of distribution; CL: clearance. compared with the control group. |