Journal of Analytical Methods in Chemistry

Research Article

Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

Table 8

Pharmacokinetic parameters of warfarin in the treated group and control group.


Pharmacokinetic parameters	Treated group	Control group

t1/2 (h)	18.46 ± 1.02	24.85 ± 17.93
T_max (h)	3.79 ± 2.46	24.85 ± 17.93
C_max (mg/L)	9.64 ± 0.70	9.60 ± 2.00
AUC0-t	161.26 ± 16.84	277.59 ± 169.67
AUC0-∞	164.51 ± 16.91	329.51 ± 260.38
V_d (L/kg)	0.33 ± 0.04	0.23 ± 0.04
CL (L/h/kg)	0.01 ± 0.00	0.01 ± 0.00

Pharmacokinetic parameters were calculated by DAS 3.2.8 software. t1/2: elimination half-life; T_max: the time of peak concentration; C_max: the maximum concentration; AUC0-t, AUC0-∞: area under the plasma concentration-time profiles; V_d: volume of distribution; CL: clearance. compared with the control group.