Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats

Table 4

The precision, accuracy, recovery, and matrix effect for seven analytes with cefuroxime in rat plasma (n = 6).

Analyte	Concentration (ng/mL)	Interday		Intraday		Recovery	Matrix effect
		RSD (%)	Accuracy RE (%)	RSD (%)	Accuracy RE (%)	(Mean ± SD, (%))	(Mean ± SD, (%))
Geniposide	77	3.80	2.52	7.16	−1.95	90.36 ± 3.64	92.79 ± 4.86
	3095	5.36	−2.82	4.60	−3.31	97.73 ± 4.72	93.31 ± 4.60
	49523	8.64	−1.26	7.56	5.53	94.78 ± 6.58	89.00 ± 2.12
Shanzhiside	10	10.68	9.10	7.39	−7.73	86.91 ± 2.57	90.62 ± 2.72
	389	9.32	−3.54	5.79	1.28	97.74 ± 4.89	87.28 ± 2.55
	6229	8.66	−1.09	3.54	2.23	89.09 ± 6.38	93.74 ± 3.55
Genipin-1-β-gentiobioside	31	11.49	2.59	4.41	−2.26	90.97 ± 5.80	92.20 ± 2.94
	1248	7.00	−3.90	4.02	2.67	88.60 ± 7.62	89.10 ± 4.99
	19962	5.25	3.77	7.49	−1.17	95.27 ± 4.80	94.40 ± 1.74
Secoxyloganin	32	9.40	2.44	6.44	4.28	92.15 ± 6.07	90.80 ± 3.89
	1288	5.50	−1.53	6.30	9.22	95.49 ± 7.38	86.84 ± 4.17
	20602	5.84	2.69	8.74	−3.11	87.55 ± 3.02	93.11 ± 3.45
Neochlorogenic acid	31	7.24	6.94	4.46	1.18	90.00 ± 6.09	89.72 ± 2.83
	1260	7.54	1.85	7.17	−1.86	87.94 ± 5.37	92.09 ± 3.72
	20152	5.53	−4.17	6.04	3.73	92.70 ± 6.38	93.07 ± 4.26
Chlorogenic acid	38	5.53	1.77	6.20	−1.52	92.53 ± 8.23	94.11 ± 3.10
	1500	6.11	1.93	7.19	2.80	92.48 ± 6.33	86.98 ± 4.64
	24000	8.23	−3.19	7.00	4.27	93.29 ± 7.44	91.74 ± 2.85
Cryptochlorogenic acid	27	8.95	5.95	6.20	−3.42	92.56 ± 5.29	91.42 ± 4.19
	1088	4.97	−1.57	8.36	1.91	91.36 ± 3.52	88.87 ± 3.97
	17402	7.18	1.48	7.44	−2.52	88.47 ± 5.30	89.28 ± 2.89
Cefuroxime	696	8.28	4.81	6.88	−4.24	101.41 ± 17.85	90.23 ± 2.98
	27850	6.22	−1.89	10.15	5.26	93.39 ± 3.98	89.51 ± 5.96
	445600	3.41	1.87	5.52	−1.21	87.62 ± 4.77	93.41 ± 1.84