Research Article
Measurement of Pharmacokinetics and Tissue Distribution of Four Compounds from Nauclea officinalis in Rat Plasma and Tissues through HPLC-MS/MS
Table 1
Optimized multiple reaction monitoring parameters for the detection of four analytes and IS.
| | Compounds | Retention time (min) | Precursor ion (m/z) | Quantitative ion (m/z) | DP (V) | CE (V) | CXP (V) |
| | Chlorogenic acid | 1.02 | 353.0 | 190.9 | −51 | −22.9 | −10.5 | | Naucleactonin C | 1.65 | 335.1 | 182.9 | −110 | −37 | −9 | | Khaephuoside A | 0.99 | 477.1 | 293.0 | −98 | −18 | −6 | | 3,4-Dimethoxyphenyl-1-O-β-apiofuroseyl(1 ⟶ 2)-β-D-glucopyranoside | 0.97 | 447.1 | 232.9 | −84 | −25 | −14 | | Chloramphenicol (IS) | 1.16 | 320.8 | 175.9 | −85 | −22 | −9 |
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Abbreviations. DP, declustering potential; CE, collision energy; CXP, collision cell exit potential.
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