A Simple and Sensitive HPLC-MS/MS Assay for the Quantitation of Blonanserin and N-Desethyl Blonanserin in Rat Plasma and Its Application to Pharmacokinetic Study

Figure 2

Representative chromatograms for rat plasma: (a) black plasma; (b) black plasma spiked with 100 ng/mL of blonanserin; (c) black plasma spiked with 100 ng/mL of N-desethyl blonanserin; (d) black plasma spiked with 20 ng/mL of the internal standards; (e) plasma sample of the lower limit of quantification; (f) plasma from rats at 5 h after single subcutaneous injection administration of blonanserin. Left: blonanserin; middle: N-desethyl blonanserin; right: N-desethyl blonanserin-d8.

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