A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice
Table 2
Intrabatch (n = 5) and interbatch (n = 15) accuracy and precision of trans-resveratrol, R3S, and R3G in mice blood at four QC levels.
Analytes
Nominal concentration (ng/mL)
Intrabatch (n = 5)
Interbatch (n = 15)
Measured concentration (ng/mL)
Precision (%)
Accuracy (%)
Measured concentration (ng/mL)
Precision (%)
Accuracy (%)
Trans-resveratrol
2.24
2.30 ± 0.25
10.91
103.23
2.31 ± 0.20
8.81
103.71
5.59
5.93 ± 0.56
9.45
106
5.52 ± 0.50
9.11
98.65
22.35
25.24 ± 0.47
1.87
112.6
23.69 ± 2.13
9.00
105.69
111.75
108 ± 4.52
4.18
96.28
107.34 ± 9.02
8.40
95.79
R3G
1.00
1.07 ± 0.15
14.00
106.9
1.03 ± 0.13
12.22
103.44
5.00
5.25 ± 0.30
6.00
104.9
5.33 ± 0.32
6.07
106.46
20.00
18.1 ± 0.91
5.00
90.48
18.31 ± 1.25
6.86
91.57
100.00
90.7 ± 4.67
5.00
90.7
96.21 ± 7.74
8.04
96.21
R3S
1.00
1.02 ± 0.08
8.11
101.50
0.96 ± 0.09
9.38
96.05
5.00
5.19 ± 0.22
4.29
103.87
5.34 ± 0.37
6.97
106.83
20.00
18.04 ± 0.61
3.00
90.30
18.67 ± 1.65
8.84
93.33
100.00
103.07 ± 9.13
8.86
103.07
100.73 ± 10.96
10.88
100.73
Data of measured concentration represented as mean ± SD. R3G, trans-resveratrol-3-o-β-glucuronide; R3S, trans-resveratrol-3-sulfate salt.
