A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice

Table 5

Pharmacokinetic parameters of trans-resveratrol and its metabolites in mice after a single intragastric administration of trans-resveratrol at a dosage of 150 mg kg^-1 (n = 6).

Analytes	Parameters (mean ± SD)
	AUC(0–12) (ng·h mL^−1)	AUC(0–∞) (ng·h mL^−1)	Cmax (ng mL^−1)	Tmax (h)	t1/2 (h)
Trans-resveratrol	8335.03 ± 4980.70	8463.70 ± 5000.20	5969.17 ± 3838.91	0.5 ± 0.282	1.90 ± 1.23
R3G	51027.06 ± 30317.97	53016.13 ± 30991.44	13799.17 ± 7070.70	0.77 ± 0.46	2.24 ± 1.04
R3S	3083.44 ± 1625.43	3163.12 ± 1624.85	971.75 ± 485.22	0.60 ± 0.27	2.08 ± 0.86

R3G, trans-resveratrol-3-o-β-glucuronide; R3S, trans-resveratrol-3-sulfate salt; AUC_(0-12), area under the plasma concentration-time curve from 0 to 12 hours; AUC_(0–∞), area under the plasma concentration-time curve from 0 to infinity hours; T_max, time to peak concentration; C_max, maximal concentration; t_1/2, eliminate half-life.