Research Article
LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study
Table 1
Optimized MRM parameters for the detection of four analytes and IS.
| | Analytes | Precursor ion (m/z) | Product ion (m/z) | Fragmentor (V) | Collision energy (eV) | Ionization mode |
| | BDCQ | 264.1 | 179 | 120 | 24 | Positive | | DCQ | 292.1 | 179 | 85 | 23 | Positive | | DHCQ | 308.2 | 130.1 | 70 | 17 | Positive | | HCQ | 336.1 | 247 | 110 | 18 | Positive | | HCQ-d4 (IS) | 340.1 | 247.1 | 90 | 20 | Positive |
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