Research Article
LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study
Table 2
Extraction recovery and matrix effect data of the analytes in rat blood (n = 6).
| Analytes | Nominal concentration (ng/mL) | Extraction recovery | Matrix effect | Mean ± SD | RSD (%) | Mean ± SD | RSD (%) |
| BDCQ | 2.5 | 90.27 ± 12.97 | 14.37 | 66.20 ± 3.84 | 5.81 | 2000 | 86.64 ± 5.45 | 6.29 | 83.14 ± 2.58 | 3.10 |
| DCQ | 2.5 | 89.59 ± 10.98 | 12.26 | 75.87 ± 4.87 | 6.42 | 2000 | 87.14 ± 4.06 | 4.66 | 85.15 ± 1.76 | 2.06 |
| DHCQ | 2.5 | 86.42 ± 12.24 | 14.16 | 77.37 ± 3.26 | 4.21 | 2000 | 92.00 ± 3.67 | 3.99 | 87.13 ± 1.83 | 2.10 |
| HCQ | 5 | 92.14 ± 9.86 | 10.70 | 73.56 ± 2.79 | 3.79 | 4000 | 93.77 ± 4.28 | 4.56 | 87.98 ± 1.44 | 1.64 |
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