UPLC-MS/MS Method for Simultaneous Determination of 14 Antimicrobials in Human Plasma and Cerebrospinal Fluid: Application to Therapeutic Drug Monitoring

Table 5

Results of the measurement of antibiotics from patients’ samples.

Analytes	Plasma samples (n)	CSF samples (n)	Patients (n)	Mean concentration (range, μg/mL)	Number below LLOQ (%)
Meropenem	23	3	17	13.14 (0.14–74.70)	2 (7.6)
Ampicillin	1	0	1	2.75	0 (0)
Linezolid	17	1	17	11.82 (0.59–42.38)	0 (0)
Ceftazidime	1	1	2	8.52 (1.4–15.64)	0 (0)
Vancomycin	73	4	65	14.38 (0.91–37.97)	0 (0)
Cefepime	4	1	5	27.92 (2.12–49.35)	0 (0)
Biapenem	6	0	6	1.72 (0.25–4.91)	0 (0)
Total	125	10	113		2 (1.4)