Rapid Characterization and Action Mechanism of the Antidiabetic Effect of Diospyros lotus L Using UHPLC-Q-Exactive Orbitrap MS and Network Pharmacology

Figure 1

The high-resolution extraction ion chromatography of Diospyros lotus L in negative ion mode (a) 167.0350, 169.0142, 191.0561, 193.0350, 218.1030, 271.0612, 287.0561, 331.0671, 355.1035, 423.0416, 431.0983, 447.0933, 463.0882, 479.0831, 597.1825, 641.1359, 755.2040; (b) 151.0401, 167.0350, 177.0193, 191.0561, 271.0612, 287.0561, 303.0510, 319.0459, 331.0671, 423.0417, 433.1140, 435.1297, 463.0882, 465.1038, 477.1038, 507.1144, 579.2083, 609.146, 613.1779, 625.1410, 641.1359, 755.2040; (c) 145.0506, 151.0401, 153.0193, 167.0350, 177.01933, 179.0350, 187.0974, 193.0506, 263.1283, 273.0768, 285.0405, 287.0561, 299.0772, 303.0510, 315.0505, 317.0303, 319.0460, 329.0878, 331.0671, 353.0878, 433.11402, 435.1297, 449.1089, 457.1351, 461.0725, 463.0890, 465.1038, 475.1457, 477.0675, 491.1195, 493.0624, 507.1144, 515.1195, 579.1719, 579.2083, 609.1461, 613.1779, 615.0992, 625.1410, 641.1359; (d) 145.0506, 151.0401, 153.0193, 167.0350, 177.0193, 179.0350, 183.0299, 193.0506, 263.1283, 281.1396, 301.0354, 303.0510, 315.0722, 319.0459, 353.0878, 359.0984, 433.1140, 435.1297, 449.1089, 457.1351, 475.1457, 477.0675, 477.1038, 491.1195, 493.0624, 493.1199, 505.0987, 579.2083, 593.1512, 609.1461, 613.1779, 615.0992, 771.1989.

(a)

(b)

(c)

(d)