Comparative Pharmacokinetic Study of Three Major Bioactive Components in the Normal and Different Courses of Liver-Stagnation and Spleen-Deficiency Syndrome Depressive Rats after Intragastric Administration of Zhi-Zi-Hou-Po Decoction
Table 3
The pharmacokinetic parameters of narirutin, naringin, and honokiol in rats of the control, CUMS, and CUMS + ZZHPD treatment group after oral administration of ZZHPD (8.5 g/kg).
Analytes
Group
Tmax (h)
Cmax (ng/mL)
t1/2 (h)
AUC0-t (h.ng/mL)
AUC0-∞ (h.ng/mL)
CL (L/h/kg)
Vd (L/kg)
Narirutin
Control
0.17 ± 0.00
7.33 ± 0.46
3.17 ± 0.47
21.95 ± 1.51
26.58 ± 2.85
54.55 ± 6.06
247.06 ± 21.90
CUMS
0.33 ± 0.00
21.03 ± 0.95
2.32 ± 0.38
31.22 ± 2.60
34.44 ± 3.62
42.06 ± 4.34
139.53 ± 16.08
CUMS + ZZHPD treatment
0.31 ± 0.07
8.34 ± 0.95###
6.01 ± 1.40###
21.23 ± 0.54###
35.93 ± 5.45
40.61 ± 5.22
343.68 ± 26.26###
Naringin
Control
0.17 ± 0.00
268.82 ± 19.96
2.66 ± 0.18
251.16 ± 16.78
264.64 ± 19.49
81.09 ± 6.07
309.90 ± 16.32
CUMS
0.36 ± 0.07
576.90 ± 45.37
2.10 ± 0.10
813.79 ± 27.30
825.82 ± 27.38
25.89 ± 0.88
78.29 ± 4.85
CUMS + ZZHPD treatment
0.17 ± 0.00###
366.67 ± 25.99###
2.81 ± 0.43##
434.98 ± 26.10###
458.33 ± 30.64###
46.78 ± 3.19###
189.15 ± 25.50###
Honokiol
Control
0.33 ± 0.00
29.72 ± 3.04
5.74 ± 1.35
96.11 ± 7.33
123.82 ± 18.11
35.46 ± 5.54
285.56 ± 34.26
CUMS
0.50 ± 0.00
70.13 ± 2.38
3.73 ± 0.63
193.74 ± 13.49
211.13 ± 20.18
20.57 ± 2.13
109.32 ± 8.81
CUMS + ZZHPD treatment
0.33 ± 0.00
30.80 ± 3.63###
4.37 ± 0.31###
92.82 ± 7.03###
108.30 ± 8.83
40.00 ± 3.27###
251.88 ± 21.01###
Note.∗∗, compared with control group;##p < 0.01,###p < 0.001, compared with CUMS group (mean ± SD, n = 6).
