Research Article
Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion
Table 1
The parameter of microwave digestion.
| Sample mass (g) | Reagents added | Initial temperature (°C) | Ramp (min) | Target temperature (°C) | Hold (min) |
| 0.2 | 5 mL of nitric acid, 50 µL of hydrofluoric acid, 0.2 mL of ICP standard Gold | Room temperature | 10 | 120 | 2 | 120 | 5 | 150 | 5 | 150 | 6 | 190 | 55 |
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