The new trends in immunochemistry related to the replacement of
radioisotopic labels with non-radioactive labels are presented. Immunoenzymatic, fluorescent and chemiluminescent techniques are described in terms of their basic principles and their most common applications. The advantages of computer-controlled calibration are also discussed.

P. A. Bonini

G. Banfi

M. Pazzagli

G. Messeri

A. Roda

Detection, signal processing, and calibration In lmmunoassay systems

Errors made during the sample preparative process contribute
significantly to the total analytical error of immunoassays. Reduction in the magnitude of these errors have been made by improvements in the manualfluid handling systems and mechanization of the individual steps in the process. The mechanization has been stimulated by developments in both computing hardware and software. A laboratory's workflow and workload will indicate the degree of mechanization required.

T. D. Geary

Sample preparation and processing

R. Haeckel

Specific requirements for automation of immunoassays in 1990

Pierangelo Bonini

Introduction

Beside general requirements for modern automated systems, immunoassay automation involves specific requirements as a separation step for heterogeneous immunoassays. Systems are designed according to the solid phase selected: dedicated or open robots for coated tubes and wells, systems nearly similar to
chemistry analysers in the case of magnetic particles, and a completely original design for those using porous and film materials.

A. Truchaud

J. Barclay

J. P. Yvert

B. Capolaghi

Automated separation for heterogeneous immunoassays

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Journal of Analytical Methods in Chemistry publishes research into the methods and instrumentation used in chemical analysis, including spectroscopic, spectrometric and wet chemistry techniques, and their applications in real-world problems.

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Chief Editor, Dr. María José Trujillo-Rodríguez, is based in the Chemistry Department (Analytical Chemistry Division) at Universidad de La Laguna, Spain.

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Journal of Analytical Methods in Chemistry publishes research into the methods and instrumentation used in chemical analysis, including spectroscopic, spectrometric and wet chemistry techniques, and their applications in real-world problems.

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