A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy
Figure 3
Sex-hormone-imbalanced 6-month-old FORKO-APPsw/PS1∆9 mice show enhanced number and hypertrophy of astrocytes and microglia in the vicinity of plaques in the hippocampus. Immunostaining for astrocytes and microglia was performed in representative areas of the cortex using polyclonal antibodies for GFAP (a) and MacII in (b) in APPsw/PS1∆9 mice and FORKO-APPsw/PS1∆9. Note that astroglia and microglia show an enlargement and increase in number, suggesting glial activation and inflammation in both APPsw/PS1∆9 FORKO-APPsw/PS1∆9 mice, more strikingly in the latter model. Scale bar measures 50 μm.
