Fiber Tracts Anomalies in APPxPS1 Transgenic Mice Modeling Alzheimer's Disease

Figure 4

Myelin stains in the cingulate cortex. In young PS1 and APPxPS1 mice myelinated axons in the cingulate cortex have a radial organization that is preserved in old PS1 mice but is severely disorganized in old APPxPS1 transgenics (lower right photo: optically empty areas correspond to amyloid plaques and are identified by black asterisks). Scale bar: 100 μm.