Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice

Figure 1

The survival curves and body weights of 𝐼𝑟^P1195L/wt mice. (a) The Kaplan-Meier survival curves of 𝐼𝑟^P1195L/wt male (𝑛=42) and 𝐼𝑟^wt/wt male (𝑛=64) mice (generalized Wilcoxon test, 𝑃=0.33). Bold and thin lines indicate 𝐼𝑟^P1195L/wt and 𝐼𝑟^wt/wt mice, respectively. (b) The Kaplan-Meier survival curves of 𝐼𝑟^P1195L/wt female (𝑛=50) and 𝐼𝑟^wt/wt female (𝑛=60) mice (generalized Wilcoxon test, 𝑃=0.42). (c, d) The body weights of male (c) and female (d) mice. The 𝐼𝑟^P1195L/wt male mice (𝑛=28) showed significantly decreased body weight compared to that of 𝐼𝑟^wt/wt male mice (𝑛=36) from 9 to 25 months of age, while the 𝐼𝑟^P1195L/wt female mice (𝑛=39) failed to show any significant difference compared to the 𝐼𝑟^wt/wt female mice (𝑛=47). Closed triangles and closed diamonds indicate 𝐼𝑟^P1195L/wt and 𝐼𝑟^wt/wt mice, respectively.

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