Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers

Table 1

Distribution of cardiovascular risk factors by genotype.

Genotype	N (%)	HTN; N (%)	CVD; N (%)	Diabetes; N (%)	Total cholesterol; mean (SD)	HDL; mean (SD)	LDL; mean (SD)	CRP; mean (SD)
APOE (𝑛=352)^1
ε2/ε3 + ε2/ε2	46 (14)	20 (43)	11 (24)	10 (22)	196.7 (49.4)	52.7 (15.6)	107.0 (41.9)	2.7 (2.6)
ε3/ε3	214 (61)	116 (54)	23 (11)	39 (18)	198.8 (39.7)	50.2 (13.9)	111.8 (34.4)	2.7 (2.9)
ε2/ε4	11 (3)	6 (55)	2 (18)	0 (0)	196.9 (39.8)	44.3 (14.8)	121.3 (27.6)	2.5 (2.6)
ε3/ε4 + ε4/ε4	81 (23)	42 (52)	9 (11)	15 (19)	199.2 (36.6)	48.3 (12.9)	116.2 (31.2)	1.7 (1.8)
		𝑃=0.62	𝑃=0.094	𝑃=0.42	𝑃=0.99	𝑃=0.19	𝑃=0.43	𝑃=0.02
ACE (𝑛=339)^2
I/I	64 (19)	38 (59)	8 (13)	10 (16)	200.2 (38.9)	52.5 (14.9)	111.9 (34.7)	2.1 (1.8)
I/D	137 (40)	67 (49)	12 (9)	26 (19)	196.7 (39.0)	49.8 (13.3)	112.0 (31.8)	2.4 (2.6)
D/D	138 (41)	74 (54)	22 (16)	25 (18)	198.9 (42.6)	48.7 (14.4)	112.5 (37.7)	2.7 (2.9)
		𝑃=0.37	𝑃=0.20	𝑃=0.85	𝑃=0.82	𝑃=0.20	𝑃=0.99	𝑃=0.32
VDR (𝑛=346)
FF	125 (36)	60 (48)	17 (14)	15 (12)	198.6 (39.1)	49.4 (14.8)	111.9 (33.3)	2.4 (2.7)
Ff	168 (49)	90 (54)	19 (11)	34 (20)	199.1 (40.9)	49.5 (13.7)	114.0 (36.0)	2.6 (2.7)
ff	53 (15)	31 (58)	8 (15)	14 (26)	197.3 (42.6)	52.2 (13.1)	109.3 (34.4)	1.9 (2.2)
		𝑃=0.40	𝑃=0.72	𝑃=0.047	𝑃=0.96	𝑃=0.43	𝑃=0.68	𝑃=0.21

¹Certain genotypes were combined for analysis, resulting in following analytic groups: (1) ε3/ε4 and ε4/ε4, (2) ε2/ε2 and ε2/ε3, (3) ε2/ε4, (4) ε3/ε3 (reference group). ²I: insertion, D: deletion.