Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats
Figure 2
Intra-hippocampal injections of pro-NGF significantly increased hippocampal expression of pro-NGF (a), but did not alter basal forebrain pro-NGF levels (b). The pro-NGF antibody was specific for pro-NGF (~32 kD) and did not detect mature NGF protein levels as shown in a pro-NGF treated animal; when incubated with pro-NGF blocking peptide, no bands were present (c). Changes in protein levels were normalized to β-Actin; .
