Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats
Figure 3
Aging resulted in an increase of p75NTR in the hippocampus (a) and basal forebrain (b), but only in the hippocampus was pro-NGF capable of significantly increasing p75NTR (a). Pro-NGF treatment decreased total hippocampal trkA (c) but did not significantly decrease total basal forebrain TrkA (d). Sortilin levels were not altered in the hippocampus (e) or basal forebrain (f). Changes in protein levels were normalized to β-Actin; .
