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Journal of Aging Research
Volume 2011, Article ID 512593, 7 pages
Research Article

The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?

1Department of Kinesiology, Louisiana State University, 112 Long Fieldhouse, Baton Rouge, LA 70803, USA
2Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA
3Harris College of Nursing and Health Sciences, Texas Christian University, TCU Box 298620, Fort Worth, TX 76129, USA
4Sports Medicine Fellowship, John Peter Smith Hospital, 701 E. I-20, Arlington, Fort Worth, TX 76018, USA

Received 10 August 2010; Revised 9 November 2010; Accepted 14 December 2010

Academic Editor: Iris Reuter

Copyright © 2011 Tara M. Henagan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 3 2 . 7 ± 3 . 7 ) women ( 6 5 . 6 ± 2 . 8  yrs) randomized to either a control ( 𝑁 = 1 1 ) or resistance training group ( 𝑁 = 1 2 ). The resistance trained group performed resistance training 3 days/week for 12 weeks. Resting blood samples were collected before and after the training intervention in both resistance trained and control groups. Resistance training upregulated melanocortin 3 receptor mRNA by 16-fold ( 𝑃 = . 0 3 5 ) and decreased monocyte count, without changing leukocyte number, body composition, or body weight. Resistance trained individuals exhibited increased sensitivity to inflammatory stimuli, whereas control individuals exhibited no change. While there was no change in whole blood tumor necrosis factor alpha mRNA between the groups, whole blood interleukin 10 mRNA was higher in the resistance trained group following the intervention period. In summary, it appears that resistance training may modulate melanocortin 3 receptor expression, providing a possible mechanism for the anti-inflammatory effects of exercise training.