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Journal of Aging Research
Volume 2011, Article ID 512593, 7 pages
http://dx.doi.org/10.4061/2011/512593
Research Article

The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?

1Department of Kinesiology, Louisiana State University, 112 Long Fieldhouse, Baton Rouge, LA 70803, USA
2Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA
3Harris College of Nursing and Health Sciences, Texas Christian University, TCU Box 298620, Fort Worth, TX 76129, USA
4Sports Medicine Fellowship, John Peter Smith Hospital, 701 E. I-20, Arlington, Fort Worth, TX 76018, USA

Received 10 August 2010; Revised 9 November 2010; Accepted 14 December 2010

Academic Editor: Iris Reuter

Copyright © 2011 Tara M. Henagan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Rizzo, E. Corrado, G. Coppola, I. Muratori, G. Novo, and S. Novo, “Markers of inflammation are strong predictors of subclinical and clinical atherosclerosis in women with hypertension,” Coronary Artery Disease, vol. 20, no. 1, pp. 15–20, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. B. K. Pedersen, “Exercise and cytokines,” Immunology and Cell Biology, vol. 78, no. 5, pp. 532–535, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. E. P. Plaisance and P. W. Grandjean, “Physical activity and high-sensitivity C-reactive protein,” Sports Medicine, vol. 36, no. 5, pp. 443–458, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Ostrowski, T. Rohde, S. Asp, P. Schjerling, and B. K. Pedersen, “Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans,” Journal of Physiology, vol. 515, no. 1, pp. 287–291, 1999. View at Google Scholar · View at Scopus
  5. K. Ostrowski, T. Rohde, M. Zacho, S. Asp, and B. K. Pedersen, “Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running,” Journal of Physiology, vol. 508, no. 3, pp. 949–953, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. M. U. Goebel, P. J. Mills, M. R. Irwin, and M. G. Ziegler, “Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways,” Psychosomatic Medicine, vol. 62, no. 4, pp. 591–598, 2000. View at Google Scholar · View at Scopus
  7. J. A. Woods, Q. Lu, M. A. Ceddia, and T. Lowder, “Exercise-induced modulation of macrophage function,” Immunology and Cell Biology, vol. 78, no. 5, pp. 545–553, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Guirao, A. Kumar, and A. Kumar, “Catecholamines increase monocyte TNF receptors and inhibit TNF through β-adrenoreceptor activation,” American Journal of Physiology, vol. 273, no. 6, part 1, pp. E1203–E1208, 1997. View at Google Scholar · View at Scopus
  9. L. K. Stewart, M. G. Flynn, and M. G. Flynn, “The influence of exercise training on inflammatory cytokines and C-reactive protein,” Medicine and Science in Sports and Exercise, vol. 39, no. 10, pp. 1714–1719, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. M. D. Phillips, M. G. Flynn, B. K. McFarlin, L. K. Stewart, and K. L. Timmerman, “Resistance training at eight-repetition maximum reduces the inflammatory milieu in elderly women,” Medicine and Science in Sports and Exercise, vol. 42, no. 2, pp. 314–325, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. Q. Lu, M. A. Ceddia, E. A. Price, S. M. Ye, and J. A. Woods, “Chronic exercise increases macrophage-mediated tumor cytolysis in young and old mice,” American Journal of Physiology, vol. 276, no. 2, pp. R482–R489, 1999. View at Google Scholar · View at Scopus
  12. A. Catania, S. Gatti, G. Colombo, and J. M. Lipton, “Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation,” Pharmacological Reviews, vol. 56, no. 1, pp. 1–29, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. Y. Konda, I. Gantz, J. DelValle, Y. Shimoto, H. Miwa, and T. Yamada, “Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor,” Journal of Biological Chemistry, vol. 269, no. 18, pp. 13162–13166, 1994. View at Google Scholar · View at Scopus
  14. R. D. Cone, “Studies on the physiological functions of the melanocortin system,” Endocrine Reviews, vol. 27, no. 7, pp. 736–749, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. M. W. Schwartz, R. J. Seeley, L. A. Campfield, P. Burn, and D. G. Baskin, “Identification of targets of leptin action in rat hypothalamus,” Journal of Clinical Investigation, vol. 98, no. 5, pp. 1101–1106, 1996. View at Google Scholar · View at Scopus
  16. Y. Zhang, G. E. Kilroy, and G. E. Kilroy, “Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin,” FASEB Journal, vol. 19, no. 11, pp. 1482–1491, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. G. N. Andersen, M. Hägglund, O. Nagaeva, L. Frängsmyr, R. Petrovska, L. Mincheva-Nilsson, and J. E. S. Wikberg, “Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes,” Scandinavian Journal of Immunology, vol. 61, no. 3, pp. 279–284, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. J. I. Mechanick, N. Levin, J. L. Roberts, and D. J. Autelitano, “Proopiomelanocortin gene expression in a distinct population of rat spleen and lung leukocytes,” Endocrinology, vol. 131, no. 1, pp. 518–525, 1992. View at Publisher · View at Google Scholar · View at Scopus
  19. S. J. Getting, L. Gibbs, A. J. L. Clark, R. J. Flower, and M. Perretti, “POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation,” Journal of Immunology, vol. 162, no. 12, pp. 7446–7453, 1999. View at Google Scholar · View at Scopus
  20. P. Redondo, J. García-Foncillas, I. Okroujnov, and E. Bandrés, “α-MSH regulates interleukin-10 expression by human keratinocytes,” Archives of Dermatological Research, vol. 290, no. 8, pp. 425–428, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. C. W. Lam, M. Perretti, and S. J. Getting, “Melanocortin receptor signaling in RAW264.7 macrophage cell line,” Peptides, vol. 27, no. 2, pp. 404–412, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. R. De Waal Malefyt, J. Abrams, B. Bennett, C. G. Figdor, and J. E. De Vries, “Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes,” Journal of Experimental Medicine, vol. 174, no. 5, pp. 1209–1220, 1991. View at Google Scholar · View at Scopus
  23. A. S. Jackson, “Research design and analysis of data procedures for predicting body density,” Medicine and Science in Sports and Exercise, vol. 16, no. 6, pp. 616–620, 1984. View at Google Scholar · View at Scopus
  24. A. S. Jackson, M. L. Pollock, and A. Ward, “Generalized equations for predicting body density of women,” Medicine and Science in Sports and Exercise, vol. 12, no. 3, pp. 175–182, 1980. View at Google Scholar · View at Scopus
  25. W. E. Siri and H. C. Lukaski, “Body composition from fluid spaces and density: analysis of methods,” Nutrition, vol. 9, no. 5, pp. 480–492, 1993. View at Google Scholar · View at Scopus
  26. R. Rauramaa, P. Halonen, and P. Halonen, “Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO study. A six-year randomized, controlled trial,” Annals of Internal Medicine, vol. 140, no. 12, pp. 1007–1014, 2004. View at Google Scholar · View at Scopus
  27. N. Brooks, J. E. Layne, P. L. Gordon, R. Roubenoff, M. E. Nelson, and C. Castaneda-Sceppa, “Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes,” International Journal of Medical Sciences, vol. 4, no. 1, pp. 19–27, 2007. View at Google Scholar · View at Scopus
  28. B. K. McFarlin, M. G. Flynn, and M. G. Flynn, “Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4,” Journals of Gerontology A, vol. 61, no. 4, pp. 388–393, 2006. View at Google Scholar · View at Scopus
  29. R. L. Starkie, J. Rolland, D. J. Angus, M. J. Anderson, and M. A. Febbraio, “Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running,” American Journal of Physiology, vol. 280, no. 4, pp. C769–C774, 2001. View at Google Scholar · View at Scopus
  30. R. L. Starkie, D. J. Angus, J. Rolland, M. Hargreaves, and M. A. Febbraio, “Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans,” Journal of Physiology, vol. 528, no. 3, pp. 647–655, 2000. View at Google Scholar · View at Scopus
  31. R. Stienstra, C. Duval, M. Müller, and S. Kersten, “PPARs, obesity, and inflammation,” PPAR Research, vol. 2007, Article ID 95974, 10 pages, 2007. View at Publisher · View at Google Scholar · View at PubMed
  32. K. L. J. Ellacott, J. G. Murphy, D. L. Marks, and R. D. Cone, “Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling,” Endocrinology, vol. 148, no. 12, pp. 6186–6194, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. J. L. Trevaskis, B. Gawronska-Kozak, G. M. Sutton, M. McNeil, J. M. Stephens, S. R. Smith, and A. A. Butler, “Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice,” Obesity, vol. 15, no. 11, pp. 2664–2672, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. G. Leoni, H. B. Patel, and H. B. Patel, “Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion,” FASEB Journal, vol. 22, no. 12, pp. 4228–4238, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. H. B. Patel, M. Bombardieri, and M. Bombardieri, “Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis,” FASEB Journal, vol. 24, no. 12, pp. 4835–4843, 2010. View at Publisher · View at Google Scholar · View at PubMed
  36. E. Maury and S. M. Brichard, “Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome,” Molecular and Cellular Endocrinology, vol. 314, no. 1, pp. 1–16, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. M. D. Phillips, M. G. Flynn, B. K. McFarlin, L. K. Stewart, K. L. Timmerman, and H. Ji, “Resistive exercise blunts LPS-stimulated TNF-α and Il-1β,” International Journal of Sports Medicine, vol. 29, no. 2, pp. 102–109, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. S. Yanagita, S. Amemiya, S. Suzuki, and I. Kita, “Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats,” Life Sciences, vol. 80, no. 4, pp. 356–363, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. P. M. Radosevich, J. A. Nash, D. B. Lacy, C. O'Donovan, P. E. Williams, and N. N. Abumrad, “Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-β-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog,” Brain Research, vol. 498, no. 1, pp. 89–98, 1989. View at Google Scholar · View at Scopus
  40. S. M. Parsadaniantz, N. Levin, V. Lenoir, J. L. Roberts, and B. Kerdelhue, “Human interleukin 1β: corticotropin releasing factor and ACTH release and gene expression in the male rat: in vivo and in vitro studies,” Journal of Neuroscience Research, vol. 37, no. 6, pp. 675–682, 1994. View at Google Scholar · View at Scopus
  41. L. Ziegler-Heitbrock, “The CD14+ CD16+ blood monocytes: their role in infection and inflammation,” Journal of Leukocyte Biology, vol. 81, no. 3, pp. 584–592, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus