Table of Contents Author Guidelines Submit a Manuscript
Journal of Aging Research
Volume 2011 (2011), Article ID 580245, 8 pages
http://dx.doi.org/10.4061/2011/580245
Research Article

Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver

School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India

Received 25 January 2011; Revised 11 May 2011; Accepted 8 July 2011

Academic Editor: Michal Masternak

Copyright © 2011 Pardeep Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Harman, “Free radical theory of aging,” Mutation Research, vol. 275, no. 3–6, pp. 257–266, 1992. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Z. Baquer, A. Taha, P. Kumar et al., “A metabolic and functional overview of brain aging linked to neurological disorders,” Biogerontology, vol. 10, no. 4, pp. 377–413, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Hou, H. Wei, Y. Luo, and G. Liu, “Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of aging,” Experimental Gerontology, vol. 45, no. 5, pp. 323–330, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Hamden, S. Carreau, F. Ellouz, H. Masmoudi, and A. El Feki, “Protective effect of 17β-estradiol on oxidative stress and liver dysfunction in aged male rats,” Journal of Physiology and Biochemistry, vol. 63, no. 3, pp. 195–202, 2007. View at Google Scholar
  5. V. W. Henderson, “Action of estrogens in the aging brain: dementia and cognitive aging,” Biochimica et Biophysica Acta, vol. 1800, no. 10, pp. 1077–1083, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Moorthy, U. C. S. Yadav, M. R. Siddiqui, D. Sharma, S. F. Basir, and N. Z. Baquer, “Effect of estradiol and progesterone treatment on carbohydrate metabolizing enzymes in tissues of aging female rats,” Biogerontology, vol. 5, no. 4, pp. 249–259, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Lu, I. Shimizu, X. Cui et al., “Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats,” Life Sciences, vol. 74, no. 7, pp. 897–907, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Hamden, S. Carreau, F. Ayadi, H. Masmoudi, and A. E. Feki, “Inhibitory effect of estrogens, phytoestrogens, and caloric restriction on oxidative stress and hepato-toxicity in aged rats,” Biomedical and Environmental Sciences, vol. 22, no. 5, pp. 381–387, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Gagliano, F. Grizzi, and G. Annoni, “Mechanisms of aging and liver functions,” Digestive Diseases, vol. 25, no. 2, pp. 118–123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Moorthy, D. Sharma, S. F. Basir, and N. Z. Baquer, “Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats,” Experimental Gerontology, vol. 40, no. 4, pp. 295–302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. N. P. Sudheesh, T. A. Ajith, V. Ramnath, and K. K. Janardhanan, “Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice,” Clinical Nutrition, vol. 29, no. 3, pp. 406–412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. P. Singh, A. J. Janecki, S. K. Srivastava et al., “Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products,” Journal of Biological Chemistry, vol. 277, no. 6, pp. 4232–4239, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. M. C. Carrillo, S. Kanai, K. Miyasaka, and K. Kitani, “A protein free diet uncovers the potential age-difference in the hepatic detoxifying system, glutathione S-transferase, in female mice,” Mechanisms of Ageing and Development, vol. 123, no. 12, pp. 1617–1623, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Martínez-Lara, E. Siles, R. Hernández et al., “Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum,” Neurobiology of Aging, vol. 24, no. 3, pp. 501–509, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. L. H. Chen, N. Hu, and D. L. Snyder, “Effects of age and dietary restriction on liver glutathione transferase activities in Lobund-Wistar rats,” Archives of Gerontology and Geriatrics, vol. 18, no. 3, pp. 191–205, 1994. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Mármol, J. Sánchez, D. López et al., “Role of oxidative stress and adenosine nucleotides in the liver of aging rats,” Physiological Research, vol. 59, no. 4, pp. 553–560, 2010. View at Google Scholar · View at Scopus
  17. K. Kitani, “Drugs and the ageing liver,” Life Chemistry Reports, vol. 6, no. 2, pp. 143–230, 1988. View at Google Scholar · View at Scopus
  18. V. V. Frolkis, A. L. Kobzar, and O. V. Sokolova, “Effects of partial hepatectomy on the plasma membrane status and the invertor mechanism of the hepatocyte Na,K-ATPase activity regulation in rats of various age,” Aging—Clinical and Experimental Research, vol. 11, no. 2, pp. 130–134, 1999. View at Google Scholar · View at Scopus
  19. V. Haynes, N. J. Traaseth, S. Elfering, Y. Fujisawa, and C. Giulivi, “Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging,” American Journal of Physiology—Endocrinology and Metabolism, vol. 298, no. 5, pp. E978–E987, 2010. View at Publisher · View at Google Scholar
  20. J. Kaur, D. Sharma, and R. Singh, “Acetyl-L-carnitine enhances Na+, K+-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions,” Neuroscience Letters, vol. 301, no. 1, pp. 1–4, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. I. Grattagliano, L. Bonfrate, C. V. Diogo, H. H. Wang, D. Q. H. Wang, and P. Portincasa, “Biochemical mechanisms in drug-induced liver injury: certainties and doubts,” World Journal of Gastroenterology, vol. 15, no. 39, pp. 4865–4876, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Tamburini, M. F. Quartacci, R. Izzo, and E. Bergamini, “Effects of dietary restriction on age-related changes in the phospholipid fatty acid composition of various rat tissues,” Aging—Clinical and Experimental Research, vol. 16, no. 6, pp. 425–431, 2004. View at Google Scholar · View at Scopus
  23. H. Berrougui and A. Khalil, “Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity,” Rejuvenation Research, vol. 12, no. 2, pp. 117–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Esterbauer, R. J. Schaur, and H. Zollner, “Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes,” Free Radical Biology and Medicine, vol. 11, no. 1, pp. 81–128, 1991. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Moorthy, U. C. S. Yadav, M. R. Siddiqui et al., “Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats,” Biogerontology, vol. 6, no. 5, pp. 345–356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Mahesh, S. Bhuvana, and V. M. H. Begum, “Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats,” Cell Biochemistry and Function, vol. 27, no. 6, pp. 358–363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Kumar, A. Taha, D. Sharma, R. K. Kale, and N. Z. Baquer, “Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity, lipid peroxidation and lipofuscin accumulation in aging rat brain regions,” Biogerontology, vol. 9, no. 4, pp. 235–246, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Kumar, A. Taha, D. Sharma, R. K. Kale, and N. Z. Baquer, “Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity, lipid peroxidation and lipofuscin accumulation in aging rat brain regions,” Biogerontology, vol. 9, no. 4, pp. 283–284, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Kumar, A. Taha, R. K. Kale, S. M. Cowsik, and N. Z. Baquer, “Physiological and biochemical effects of 17β estradiol in aging female rat brain,” Experimental Gerontology, vol. 46, no. 7, pp. 597–605, 2011. View at Publisher · View at Google Scholar
  30. M. R. Siddiqui, A. Taha, K. Moorthy, M. E. Hussain, S. F. Basir, and N. Z. Baquer, “Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains,” Journal of Biosciences, vol. 30, no. 4, pp. 483–490, 2005. View at Google Scholar · View at Scopus
  31. S. Marklund and G. Marklund, “Involvement of the super anion radicals in the autoxidation of pyrogollol and a convenient assay for superoxide dismutase,” European Journal of Biochemistry, vol. 47, pp. 469–474, 1974. View at Google Scholar
  32. B. L. Gupta, A. Preet, and N. Z. Baquer, “Protective effects of sodium orthovanadate in diabetic reticulocytes and ageing red blood cells of Wistar rats,” Journal of Biosciences, vol. 29, no. 1, pp. 73–79, 2004. View at Google Scholar · View at Scopus
  33. C. S. K. Mayanil, S. M. I. Kazmi, and N. Z. Baquer, “Na+, K+-ATPase and Mg2+-ATPase activities in different regions of rat brain during alloxan diabetes,” Journal of Neurochemistry, vol. 39, no. 4, pp. 903–908, 1982. View at Google Scholar · View at Scopus
  34. D. Desaiah, C. S. Chetty, and K. S. Prasada Rao, “Chlordecone inhibition of calmodulin activated calcium ATPase in rat brain synaptosomes,” Journal of Toxicology and Environmental Health, vol. 16, no. 2, pp. 189–195, 1985. View at Google Scholar · View at Scopus
  35. S. Genet, R. K. Kale, and N. Z. Baquer, “Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonella foenum graecum),” Molecular and Cellular Biochemistry, vol. 236, no. 1-2, pp. 7–12, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Tappel, B. Fletcher, and D. Deamer, “Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse,” Journals of Gerontology, vol. 28, no. 4, pp. 415–424, 1973. View at Google Scholar · View at Scopus
  37. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  38. S. N. Hilmer, V. C. Cogger, and D. G. Le Couteur, “Basal activity of kupffer cells increases with old age,” Journals of Gerontology—Series A Biological Sciences and Medical Sciences, vol. 62, no. 9, pp. 973–978, 2007. View at Google Scholar · View at Scopus
  39. A. Ayala, M. M. Perrin, W. Ertel, and I. H. Chaudry, “Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release,” Cytokine, vol. 4, no. 1, pp. 66–75, 1992. View at Google Scholar · View at Scopus
  40. R. A. Kireev, A. C. F. Tresguerres, C. Garcia et al., “Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomizedfemale rats,” Biogerontology, vol. 11, no. 2, pp. 229–243, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Sener, S. Arbak, P. Kurtaran, N. Gedik, and B. C. Yegen, “Estrogen protects the liver and intestines against sepsis-induced injury in rats,” Journal of Surgical Research, vol. 128, no. 1, pp. 70–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. A. K. Mantha, K. Moorthy, S. M. Cowsik, and N. Z. Baquer, “Membrane associated functions of neurokinin B (NKB) on Aβ (25–35) induced toxicity in aging rat brain synaptosomes,” Biogerontology, vol. 7, no. 1, pp. 19–33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. K. D. Tew and Z. Ronai, “GST function in drug and stress response,” Drug Resistance Updates, vol. 2, no. 3, pp. 143–147, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Ulas and M. Cay, “The effects of 17β-estradiol and vitamin e treatments on oxidative stress and antioxidant levels in brain cortex of diabetic ovariectomized rats,” Acta Physiologica Hungarica, vol. 97, no. 2, pp. 208–215, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. R. A. Kireev, A. F. Tresguerres, E. Vara, C. Ariznavarreta, and J. A. F. Tresguerres, “Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats,” Biogerontology, vol. 8, no. 5, pp. 469–482, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Viña, M. C. Gomez-Cabrera, and C. Borras, “Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation?” British Journal of Nutrition, vol. 98, supplement 1, pp. S36–S40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Viña, J. Sastre, F. V. Pallardó, J. Gambini, and C. Borrás, “Modulation of longevity-associated genes by estrogens or phytoestrogens,” Biological Chemistry, vol. 389, no. 3, pp. 273–277, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Viña and C. Borrás, “Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds,” Antioxidants and Redox Signaling, vol. 13, no. 3, pp. 269–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. I. Shimizu and S. Ito, “Protection of estrogens against the progression of chronic liver disease,” Hepatology Research, vol. 37, no. 4, pp. 239–247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Hashimoto, M. H. Shahdat, T. Shimada et al., “Relationship between age-related increases in rat liver lipid peroxidation and bile canalicular plasma membrane fluidity,” Experimental Gerontology, vol. 37, no. 1, pp. 89–97, 2001. View at Publisher · View at Google Scholar · View at Scopus
  51. X. Wang, Y. Liao, G. Li, D. Yin, and S. Sheng, “A comparative study of artificial ceroid/lipofuscin from different tissue materials of rats,” Experimental Aging Research, vol. 34, no. 3, pp. 282–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. P. Kumar, R. K. Kale, P. McLean, and N. Z. Baquer, “Protective effects of 17β estradiol on altered age related neuronal parameters in female rat brain,” Neuroscience Letters, vol. 502, no. 1, pp. 56–60, 2011. View at Publisher · View at Google Scholar
  53. H. Berrougui and A. Khalil, “Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity,” Rejuvenation Research, vol. 12, no. 2, pp. 117–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Kumar, R. K. Kale, and N. Z. Baquer, New Frontiers in Molecular Mechanisms of Neurological and Psychiatric Disorders, ISBN no. 97880-8886699, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia, 2011.