Estradiol Modulates Membrane-Linked ATPases, Antioxidant Enzymes, Membrane Fluidity, Lipid Peroxidation, and Lipofuscin in Aged Rat Liver

Table 1

Body weight and protein concentration of 3, 12, and 24 months of control (C) and estradiol- (E2-) treated aging female rats.

Age/treatment	Body wt. (g)	Protein content (mg/g)
		Whole homogenate	Supernatant	Mitochondria
3 months
C	218±23	168±17.3	129±9.3	17.9±1.6
12 months
C	330±18^∗	160±18.5	110±4.9	19.5±2.1
E2	243±27	164±7.9	118±8.6	20.8±2.7
24 months
C	425±36^$	156±13.6	108±7.4	17.2±1.4
E2	292±28^c	162±8.3	120±4.5	18.6±1.2

Each value is a mean ± SEM of five or more separate values from two to three experiments. The comparisons of experimental values are with the control values. Statistical significance: ^c𝑃<0.05 comparing age-matched controls versus E2 treatment and ^$𝑃<0.001, ^∗𝑃<0.05 versus 3 months.