Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels
Figure 5
Balanced NO metabolism is required for CR-induced beneficial effects. (a) CR fails to extend RLS in cells lacking Sfa1 and Yhb1. (b) CR genetic mimics fail to extend RLS in cells lacking Sfa1 and Yhb1. (c) Deleting Sfa1 and Yhb1 partially affect CR-induced increase in oxygen consumption and NO levels. (d) Sfa1 and Yhb1 are not required for CR-induced CLS. One representative set of experiments is shown. Error bars denote standard deviations. values are calculated using Student’s -test (*; **; ***).
