Journal of Aging Research / 2011 / Article / Tab 2

Review Article

Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging

Table 2

Proteomic identification of mitochondrial proteins during skeletal muscle aging.

Proteomic studyChanges in mitochondrial marker proteinsReference

Analysis of total extracts from aged human vastus lateralis muscleGeneral increase in aerobic markers, including mitochondrial enzymes such as ATP synthase, ubiquinol-cytochrome c reductase, and oxoglutarate dehydrogenase during muscle agingGelfi et al. [86]
Analysis of total extracts from rat gastrocnemius muscleIncrease in mitochondrial enzymes, such as succinate dehydrogenase, isocitrate dehydrogenase, ATP synthase, and malate dehydrogenase during muscle agingDoran et al. [93]
Analysis of total extracts from rat gastrocnemius muscleDifferential effect on the abundance of mitochondrial isoforms of aconitase during muscle agingO’Connell et al. [87]
Analysis of total extracts from aged rat gastrocnemius muscleModerate effect on cytochrome c oxidase and isocitrate dehydrogenase during muscle agingPiec et al. [85]
Analysis of total extracts from rat gastrocnemius muscleIncrease in many enzymes involved in oxidative metabolism, such as ATP synthase, isocitrate dehydrogenase, ubiquinol-cytochrome c reductase, and pyruvate dehydrogenase during muscle agingCapitanio et al. [94]
Subproteomic study of the effect of aging and caloric restriction on rat muscle mitochondriaIncreased levels of isocitrate dehydrogenase and malate dehydrogenase in aged muscle mitochondria. Caloric restriction appears to have only a marginal effect on the mitochondrial proteomeChang et al. [90]
Subproteomic analysis of mitochondria-enriched fraction from aged rat gastrocnemius muscleIncreased levels of mitochondrial creatine kinase, NADH dehydrogenase, ATP synthase, succinate dehydrogenase, and ubiquinol cytochrome c reductase during muscle aging O’Connell and Ohlendieck [97]
Analysis of total extracts and mitochondria-enriched fraction from aged ratgastrocnemius muscleDifferential effect on mitochondrial enzymes, such as pyruvate dehyrdogenase, cytochrome c oxidase, isocitrate dehydrogenase, and ATP synthase during muscle agingLombardi et al. [96]
Subproteomic analysis of mitochondria-enriched fraction from aged mouse hind limb musclesDifferential effects on the abundance and carbonylation of various mitochondrial enzymes, including NADH dehydrogenase, cytochrome c oxidase, and ATP synthase during muscle agingAlves et al. [98]
Analysis of detergent phase-extracted protein complement from aged rat gastrocnemius muscleIncrease in mitochondrial marker enzymes, such as ATP synthase and isocitrate dehydrogenase during muscle agingDonoghue et al. [99]
Proteomic analysis of nitration in aged rat skeletal muscleIncreased nitration levels in succinate dehydrogenaseKanski et al. [84]
Phosphoproteomic analysis of total extracts from aged rat gastrocnemius muscleDecreased phosphorylation levels in cytochrome c oxidase and aconitase during muscle agingGannon et al. [92]
Proteomic analysis of carbonylation in aged rat skeletal muscle mitochondriaAltered carbonylation levels in numerous mitochondrial proteins, including ATP synthase, NADH dehydrogenase, pyruvate dehydrogenase, and isocitrate dehydrogenase during muscle agingFeng et al. [91]

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