Journal of Aging Research / 2011 / Article / Fig 3

Review Article

Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes

Figure 3

White matter changes after BCAS. Photomicrographs of Klüver-Barrera staining in the cerebral cortex (a, b), corpus callosum (c, d), and caudoputamen (e, f). The left column (a, c, e) indicates the brain from a sham-operated mouse, and the right column (b, d, f) indicates a brain after BCAS-operated mouse using microcoils with 0.18 mm diameter for 30 days. Note that the WM changes are the most intense in the medial part of the corpus callosum adjacent to the lateral ventricle (arrows). The histogram shows temporal profiles of the WM changes, the severity of which is semiquantitatively graded into four levels (g). Scale bar, 500 μm (a, b), 50 μm (c, d), and 25 μm (e, f).

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