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Journal of Aging Research
Volume 2011, Article ID 985703, 8 pages
http://dx.doi.org/10.4061/2011/985703
Research Article

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

1Department of Pediatrics and Gulf States Hemophilia & Thrombophilia Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
2Department of Internal Medicine and Gulf States Hemophilia & Thrombophilia Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA

Received 21 March 2011; Revised 27 May 2011; Accepted 7 July 2011

Academic Editor: Arshad Jahangir

Copyright © 2011 Aroub A. Khleif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Dolan, “The challenge of an ageing haemophilic population,” Haemophilia, vol. 16, no. 5, pp. 11–16, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. M. Franchini and P. M. Mannucci, “Co-morbidities and quality of life in elderly persons with haemophilia,” British Journal of Haematology, vol. 148, no. 4, pp. 522–533, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. E. Ikkala, T. Hilske, and G. Myllyla, “Changes in the life expectancy of patients with severe haemophilia A in Finland in 1930–1979,” British Journal of Haematology, vol. 52, no. 1, pp. 7–12, 1982. View at Google Scholar
  4. E. P. Mauser-Bunschoten, D. E. Fransen Van De Putte, and R. E. G. Schutgens, “Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy,” Haemophilia, vol. 15, no. 4, pp. 853–863, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. W. Miesbach, S. Alesci, S. Krekeler, and E. Seifried, “Comorbidities and bleeding pattern in elderly haemophilia A patients,” Haemophilia, vol. 15, no. 4, pp. 894–899, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. J. Oldenburg, G. Dolan, and G. Lemm, “Haemophilia care then, now and in the future,” Haemophilia, vol. 15, no. 1, pp. 2–7, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. I. Plug, J. G. Van Der Bom, M. Peters et al., “Mortality and causes of death in patients with hemophilia, 1992–2001: a prospective cohort study,” Journal of Thrombosis and Haemostasis, vol. 4, no. 3, pp. 510–516, 2006. View at Publisher · View at Google Scholar · View at PubMed
  8. F. R. Rosendaal, I. Varekamp, C. Smit et al., “Mortality and causes of death in Dutch haemophiliacs, 1973–1986,” British Journal of Haematology, vol. 71, no. 1, pp. 71–76, 1989. View at Google Scholar · View at Scopus
  9. S. M. Siboni, P. M. Mannucci, A. Gringeri et al., “Health status and quality of life of elderly persons with severe hemophilia born before the advent of modern replacement therapy,” Journal of Thrombosis and Haemostasis, vol. 7, no. 5, pp. 780–786, 2009. View at Publisher · View at Google Scholar · View at PubMed
  10. A. M. Street, K. Hill, B. Sussex, M. Warner, and M. F. Scully, “Haemophilia and ageing,” Haemophilia, vol. 12, no. 3, pp. 8–12, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. B. A. Konkle, C. Kessler, L. Aledort et al., “Emerging clinical concerns in the ageing haemophilia patient,” Haemophilia, vol. 15, no. 6, pp. 1197–1209, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. D. M. Arnold, J. A. Julian, and I. R. Walker, “Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up,” Blood, vol. 108, no. 2, pp. 460–464, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. S. C. Darby, W. K. Sau, R. J. Spooner et al., “Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV,” Blood, vol. 110, no. 3, pp. 815–825, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. P. M. Mannucci, R. E. G. Schutgens, E. Santagostino, and E. P. Mauser-Bunschoten, “How I treat age-related morbidities in elderly persons with hemophilia,” Blood, vol. 114, no. 26, pp. 5256–5263, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. StataCorp, Stata Statistical Software, Release 11.0, Stata Corporation, College Station, Tex, USA.
  16. G. M. McQuillan, D. Kruszon-Moran, B. J. Kottiri et al., “Prevalence of HIV in the US household population: the national health and nutrition examination surveys, 1988 to 2002,” Journal of Acquired Immune Deficiency Syndromes, vol. 41, no. 5, pp. 651–656, 2006. View at Publisher · View at Google Scholar · View at PubMed
  17. G. L. Armstrong, A. Wasley, E. P. Simard, G. M. McQuillan, W. L. Kuhnert, and M. J. Alter, “The prevalence of hepatitis C virus infection in the United States, 1999 through 2002,” Annals of Internal Medicine, vol. 144, no. 10, pp. 705–714, 2006. View at Google Scholar
  18. K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999–2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at PubMed
  19. W. Rosamond, K. Flegal, K. Furie et al., “Heart disease and stroke statistics-2008 update: a report from the American heart association statistics committee and stroke statistics subcommittee,” Circulation, vol. 117, no. 4, pp. e25–e146, 2008. View at Publisher · View at Google Scholar · View at PubMed
  20. National Center for Health Statistics, “Health, United States, 2009,” Tech. Rep., National Center for Health Statistics, Hyattsville, Md, USA, 2010. View at Google Scholar
  21. C. Vogeli, A. E. Shields, T. A. Lee et al., “Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs,” Journal of General Internal Medicine, vol. 22, no. 3, pp. 391–395, 2007. View at Publisher · View at Google Scholar · View at PubMed
  22. G. Dolan, C. Hermans, R. Klamroth, R. Madhok, R. E. G. Schutgens, and U. Spencer, “Challenges and controversies in haemophilia care in adulthood,” Haemophilia, vol. 15, no. 1, pp. 20–27, 2009. View at Publisher · View at Google Scholar · View at PubMed
  23. M. G. Rumi, F. De Filippi, E. Santagostino, and M. Colombo, “Hepatitis C in haemophilia: lights and shadows,” Haemophilia, Supplement, vol. 10, no. 4, pp. 211–215, 2004. View at Google Scholar
  24. B. Kupfer, T. Ruf, B. Matz et al., “Comparison of GB virus C, HIV, and HCV infection markers in hemophiliacs exposed to non-inactivated or inactivated factor concentrates,” Journal of Clinical Virology, vol. 34, no. 1, pp. 42–47, 2005. View at Publisher · View at Google Scholar · View at PubMed
  25. S. F. Altekruse, K. A. McGlynn, and M. E. Reichman, “Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005,” Journal of Clinical Oncology, vol. 27, no. 9, pp. 1485–1491, 2009. View at Publisher · View at Google Scholar · View at PubMed
  26. J. R. Neyer, K. J. Greenlund, C. H. Denny, N. L. Keenan, D. R. Labarthe, and J. B. Croft, “Prevalence of heart disease—United States, 2005,” Morbidity and Mortality Weekly Report, vol. 56, no. 6, pp. 113–118, 2007. View at Google Scholar
  27. R. Kulkarni, J. M. Soucie, B. L. Evatt et al., “Prevalence and risk factors for heart disease among males with hemophilia,” American Journal of Hematology, vol. 79, no. 1, pp. 36–42, 2005. View at Publisher · View at Google Scholar · View at PubMed
  28. A. Tuinenburg, E. P. Mauser-Bunschoten, M. C. Verhaar, D. H. Biesma, and R. E.G. Schutgens, “Cardiovascular disease in patients with hemophilia,” Journal of Thrombosis and Haemostasis, vol. 7, no. 2, pp. 247–254, 2009. View at Publisher · View at Google Scholar · View at PubMed
  29. F. G. Hofstede, K. Fijnvandraat, I. Plug, P. W. Kamphuisen, F. R. Rosendaal, and M. Peters, “Obesity: a new disaster for haemophilic patients? A nationwide survey,” Haemophilia, vol. 14, no. 5, pp. 1035–1038, 2008. View at Publisher · View at Google Scholar · View at PubMed
  30. M. Walsh, D. Macgregor, S. Stuckless, B. Barrett, M. Kawaja, and M. F. Scully, “Health-related quality of life in a cohort of adult patients with mild hemophilia A,” Journal of Thrombosis and Haemostasis, vol. 6, no. 5, pp. 755–761, 2008. View at Publisher · View at Google Scholar · View at PubMed
  31. J. M. Soucie, R. Nuss, B. Evatt et al., “Mortality among males with hemophilia: relations with source of medical care,” Blood, vol. 96, no. 2, pp. 437–442, 2000. View at Google Scholar
  32. A. Lambing, P. Kuriakose, J. Lanzon, and E. Kachalsky, “Dialysis in the haemophilia patient: a practical approach to care,” Haemophilia, vol. 15, no. 1, pp. 33–42, 2009. View at Publisher · View at Google Scholar · View at PubMed
  33. J. M. Valderas, B. Starfield, B. Sibbald, C. Salisbury, and M. Roland, “Defining comorbidity: implications for understanding health and health services,” Annals of Family Medicine, vol. 7, no. 4, pp. 357–363, 2009. View at Publisher · View at Google Scholar · View at PubMed