Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care

Table 3

Prevalence estimates and 95% confidence intervals of co-morbid conditions among hemophilia patients compared to the general US male population, by selected characteristics.

Condition	Hemophilia A and B patients (𝑁=63)			Prevalence in general US male population^†
	𝑛	%	95% CI^‡	%
Total number of co-morbid conditions^††
1-2	16	25.4	14.35, 36.45
3-4	22	34.9	22.82, 47.02
5-6	17	27.0	15.72, 38.25
≥7	8	12.7	4.24, 21.15
HIV positive	16	25.4	14.35, 36.45	^a40–49 years: 0.74
40–49 years	11	37.9	19.15, 56.71
HCV positive	49	77.8	67.22, 88.33	^b40–49 years: ~ 6; 50–59: 1.6; ≥60 years: 0.9
40–49 years	21	72.4	55.11, 89.72
50–59 years	15	83.3	64.26, 99.02
≥60 years	13	81.3	59.77, 99.03
BMI
Normal (18.5–24.9)	22	34.9	22.82, 47.02
Overweight (25.0–29.9)	25	39.7	27.26, 52.10
Obese (≥30)	16	25.4	14.34, 36.45
BMI ≥25.0				^cBMI≥25.0; 40–59 years: 77.8; ≥60 years: 78.4
40–59 years	33	70.2	56.64, 83.79
≥60 years	8	50.0	22.48, 77.52
BMI ≥30.0				^cBMI≥30.0; 40–59 years: 34.3; ≥60 years: 37.1
40–59 years	13	27.7	14.38, 40.93
≥60 years	3	18.8	—
BMI ≥35.0				^cBMI≥35.0; 40–59 years: 11.6; ≥60 years: 11.6
40–59 years	6	12.8	2.8, 22.67
≥60 years	1	6.3	—
BMI ≥40.0				^cBMI≥40.0; 40–59 years: 4.2; ≥60 years: 4.2
40–59 years	2	4.3	—
≥60 years	—	—	—
Cardiovascular disease^†††	30	47.6	34.94, 60.30	^d40-59 years: 39.1; ≥60 years: 71.3
40–59 years	19	40.4	25.86, 54.99
≥60 years	11	68.8	43.24, 94.26
Hypertension	29	46.0	33.38, 58.69
40–44 years	6	46.2	14.80, 77.51	^e45-54 years: 36.2; 55–64 years: 50.2; 65–74 years: 64.1; ≥75 years: 65.0
45–54 years	7	30.4	10.09, 50.78
55–64 years	8	53.3	24.74, 81.93
65–74 years	6	60.0	23.06, 96.94
≥75 years	2	100	—
Hypercholesterolemia	10	15.9	6.60, 25.15
45–54 years	4	17.4	0.63, 34.15	^e45-54 years: 36.2; 55–64 years: 50.2; 65–74 years: 64.1; ≥75 years: 65.0
55–64 years	2	13.3	—
65–74 years	2	20.0	—
≥75 years	1	50.0	—
Chronic arthropathy	33	52.4	39.70, 65.06
40–59 years	22	46.8	32.00, 61.62
≥60 years	11	68.8	43.24, 94.26
HBV positive	4	6.4	0.16, 12.54
Diabetes	9	14.3	5.40, 23.17
Renal disease	5	7.9	1.07, 14.80
Depression	5	7.9	1.07, 14.80
Respiratory disease	7	11.1	3.13, 19.09
Gastrointestinal disease	3	4.8	—
Thyroid disease	4	6.4	0.16, 12.54
Neurological disease	3	4.8	—
Cancer	10	15.9	6.60, 25.15
Hepatocellular carcinoma	7	70.0
Non-Hodgkin’s lymphoma	1	10.0
Lung cancer	1	10.0
Leukemia	1	10.0

^‡CI: Confidence interval,
^†Prevalence estimates reported when data were available:
^asee [16].
^bsee [17].
^csee [18].
^dsee [19].
^esee [20].
^††Number of conditions excluding hemophilia disease.
^†††Includes patients with cardiovascular disease, hypertension, and stroke.