Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane

<table>LDH release during reperfusion in isolated rat hearts (a). LDH activity in coronary effluent during 30 min reperfusion was measured in order to assess myocardial injury. Amobarbital given at the onset of reperfusion markedly decreased LDH release compared to untreated hearts, supporting that the modulation of mitochondrial respiration during early reperfusion decreased myocardial injury in the aged hearts. Amobarbital treatment also decreased LDH release in buffer perfused mouse hearts (b) and myocardial infarct size (c). (Mean ± SEM; *<svg height="11.25" id="M6" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</svg> versus untreated hearts <svg height="7.1374998" id="M7" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-66.29)">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
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</svg> = 6–10 in each group.)</table>

Journal of Aging Research

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Figure 3

Figure 3: Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane 

Figure 3 | Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane 