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Journal of Aging Research
Volume 2014, Article ID 153127, 14 pages
Review Article

Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

1Center for Diagnostic Nanosystems and Robert C. Byrd Biotechnology Science Center, Marshall University, Room 241D, 1700 3rd Avenue, Huntington, WV 25755-1090, USA
2Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA
3Department of Pharmacy Practice, Administration, and Research, School of Pharmacy, Marshall University, Huntington, WV, USA
4Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA

Received 14 August 2014; Revised 5 December 2014; Accepted 5 December 2014; Published 31 December 2014

Academic Editor: F. R. Ferraro

Copyright © 2014 K. M. Rice et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.