Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging

Table 2

Baseline hemodynamics across infusion trials in young and older adults^a,b.

	Saline	L-NMMA	KETO + L-NMMA	Trial
Young (𝑛=16)^c
RA diameter (mm)	2.09 ± 0.35	2.08 ± 0.34	2.08 ± 0.36	0.68
RBF (mL/min)	16.4 ± 14.2	11.7 ± 7.5	11.7 ± 5.4	0.05
MAP (mmHg)	77.5 ± 9.9	80.6 ± 11.6	84.0 ± 12.6*	0.01
RVC (mL/min/100 mmHg)	20.9 ± 17.7	14.5 ± 9.6*	14.0 ± 6.3*	0.03
Older (𝑛=10)
RA diameter (mm)	2.16 ± 0.42	2.12 ± 0.36	2.05 ± 0.46	0.32
RBF (mL/min)	18.0 ± 5.9	13.2 ± 4.0	11.9 ± 6.1	0.01
MAP (mmHg)	82.7 ± 9.4	87.9 ± 11.0	90.3 ± 10.2*	0.01
RVC (mL/min/100 mmHg)	22.9 ± 8.9	15.1 ± 4.4*	13.3 ± 6.9*	0.01

aData are means ± SD.
^bKETO: ketorolac; L-NMMA: N(G)-monomethyl-L-arginine; MAP: mean arterial pressure; RA: radial artery; RBF: radial artery blood flow; RVC: radial artery vascular conductance.
^cData from young participants have been published previously [8].
*Significantly different from saline trial (𝑃<0.05). Trial = 𝑃 value for trial effect for each variable.