Journal of Aging Research / 2016 / Article / Tab 1

Review Article

HIV Infection in the Elderly: Arising Challenges

Table 1

Studies evaluating immunological and clinical responses to HAART.

Study, yearAspect studiedMain findings

Semeere et al., 2014 [44]Immunological recovery by ageAdults younger than 50 years had on average a higher CD4 increase of 45 cells per cubic millimeter (95% confidence interval: 17 to 72; = 0.001) compared with counterparts aged 60 years and older; mortality was highest among older adults compared with younger counterparts

Grabar et al., 2004 [8]Immunologic and clinical responses to HAART in patients over 50 years oldCD4 mean increase during the first 6 months on HAART was +42.9 × 106 cells/L per month in patients under 50 years and +36.9 × 106 cells/L per month in patients over 50 years ( < 0.0001)
Older patients had a significantly higher risk of clinical progression (hazard ratio (HR) = 1.52 [95% confidence interval (CI), 1.15–2.00])

Mutevedzi et al., 2011 [45]To assess whether treatment outcomes vary with age for adults receiving antiretroviral therapyOlder adults had 32% excess mortality (= 0.004)
CD4 count reconstitution was lower, despite better virological response in the older adults

Maskew et al., 2012 [46]Differences in treatment outcomes by age categoryThe adjusted hazard ratios (HRs) for all-cause mortality increased with increasing age
Older patients were less likely to increase their CD4 count by ≥50 cells/mm

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