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Journal of Aging Research
Volume 2016, Article ID 5081021, 20 pages
http://dx.doi.org/10.1155/2016/5081021
Review Article

The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases

1Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3016, Chuo Kikuu, Morogoro, Tanzania
2Department of Basic Health Sciences, Qassim University, Buraydah, Al-Qassim 51452, Saudi Arabia

Received 13 May 2016; Accepted 21 July 2016

Academic Editor: Elke Bromberg

Copyright © 2016 Maulilio John Kipanyula et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Daniela Valenti, Nady Braidy, Domenico De Rasmo, Anna Signorile, Leonardo Rossi, Atanas Georgiev Atanasov, Mariateresa Volpicella, Alexandra Henrion-Caude, Seyed Mohammad Nabavi, and Rosa Anna Vacca, “Mitochondria as Pharmacological Targets in Down syndrome,” Free Radical Biology and Medicine, 2017. View at Publisher · View at Google Scholar
  • Malwina Lisek, Tomasz Boczek, and Ludmila Zylinska, “Calcium as a Trojan horse in mental diseases—The role of PMCA and PMCA-interacting proteins in bipolar disorder and schizophrenia.,” Neuroscience Letters, 2017. View at Publisher · View at Google Scholar
  • Mark Halliday, Daniel Hughes, and Giovanna R. Mallucci, “Fine-tuning PERK signaling for neuroprotection,” Journal of Neurochemistry, 2017. View at Publisher · View at Google Scholar
  • Benjamin M Zemel, Tanziyah Muqeem, Eric V Brown, Miguel Goulão, Mark W Urban, Stephen R Tymanskyj, Angelo C Lepore, and Manuel Covarrubias, “Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons.,” The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 37, no. 34, pp. 8256–8272, 2017. View at Publisher · View at Google Scholar
  • Hanna Vihma, and T?nis Timmusk, “Sumoylation regulates the transcriptional activity of different human NFAT isoforms in neurons,” Neuroscience Letters, vol. 653, pp. 302–307, 2017. View at Publisher · View at Google Scholar
  • Man Liu, Rumana Yasmeen, Naomi Fukagawa, Liangli Yu, Young Kim, and Thomas Wang, “Dose-Dependent Responses of I3C and DIM on T-Cell Activation in the Human T Lymphocyte Jurkat Cell Line,” International Journal of Molecular Sciences, vol. 18, no. 7, pp. 1409, 2017. View at Publisher · View at Google Scholar
  • Fr?d?ric Gu?nard, Annie Bouchard-Mercier, Iwona Rudkowska, Simone Lemieux, Patrick Couture, and Marie-Claude Vohl, “Genome-Wide Association Study of Dietary Pattern Scores,” Nutrients, vol. 9, no. 7, pp. 649, 2017. View at Publisher · View at Google Scholar
  • Angela R. Wild, and Mark L. Dell’Acqua, “Potential for Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders,” Pharmacology & Therapeutics, 2017. View at Publisher · View at Google Scholar
  • Andreas Aufschnaiter, Verena Kohler, and Sabrina Büttner, “Taking out the garbage: cathepsin D and calcineurin in neurodegeneration,” Neural Regeneration Research, vol. 12, no. 11, pp. 1776, 2017. View at Publisher · View at Google Scholar
  • Małgorzata Rydzanicz, Małgorzata Wachowska, Erik C. Cook, Paweł Lisowski, Bożena Kuźniewska, Krystyna Szymańska, Sebastian Diecke, Alessandro Prigione, Krzysztof Szczałuba, Aleksandra Szybińska, Agnieszka Koppolu, Victor Murcia Pienkowski, Joanna Kosińska, Małgorzata Wiweger, Grażyna Kostrzewa, Małgorzata Brzozowska, Dorota Domańska-Pakieła, Elżbieta Jurkiewicz, Piotr Stawiński, Agnieszka Gromadka, Piotr Zielenkiewicz, Urszula Demkow, Magdalena Dziembowska, Jacek Kuźnicki, Trevor P. Creamer, and Rafał Płoski, “Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression,” European Journal of Human Genetics, 2018. View at Publisher · View at Google Scholar
  • Zhen Tan, Ting Kang, Xiuli Zhang, Yingying Tong, and Siyu Chen, “Nerve growth factor prevents arsenic-induced toxicity in PC12 cells through the AKT/GSK-3β/NFAT pathway,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, and Daniela Galimberti, “LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients,” Journal of Neuroimmunology, 2018. View at Publisher · View at Google Scholar
  • Jackson Saraf, Pallab Bhattacharya, Kiran Kalia, Anupom Borah, Deepaneeta Sarmah, Harpreet Kaur, Kunjan R Dave, and Dileep R Yavagal, “A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders,” ACS Central Science, 2018. View at Publisher · View at Google Scholar
  • E. O. Tarasova, A. E. Gaydukov, and O. P. Balezina, “Calcineurin and Its Role in Synaptic Transmission,” Biochemistry (Moscow), vol. 83, no. 6, pp. 674–689, 2018. View at Publisher · View at Google Scholar
  • Sahba Seddighi, Vijay Varma, and Madhav Thambisetty, “α2-macroglobulin in Alzheimer's disease: new roles for an old chaperone,” Biomarkers in Medicine, 2018. View at Publisher · View at Google Scholar
  • Nesly Dotan, Vera Gayder, Itai Bloch, and Maayan Gal, “An ELISA for the study of calcineurin-NFAT unstructured region interaction,” Analytical Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Ketan K. Marballi, and Amelia L. Gallitano, “Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia,” Frontiers in Behavioral Neuroscience, vol. 12, 2018. View at Publisher · View at Google Scholar
  • Maria E. Cardenas, Ci Fu, Joseph Heitman, and Nicholas Donadio, “Dissecting the roles of the calcineurin pathway in unisexual reproduction, stress responses, and virulence in cryptococcus deneoformans,” Genetics, vol. 208, no. 2, pp. 639–653, 2018. View at Publisher · View at Google Scholar
  • Yue Yang, Song Li, Zi-Run Jin, Hong-Bo Jing, Hong-Yan Zhao, Bo-Heng Liu, Ya-Jing Liang, Ling-Yu Liu, Jie Cai, You Wan, and Guo-Gang Xing, “Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis,” Science Signaling, vol. 11, no. 552, pp. eaao5150, 2018. View at Publisher · View at Google Scholar
  • Dmitry Lim, Pier Luigi Canonico, Armando A. Genazzani, Lisa Mapelli, and Francesco Moccia, “Neuronal activity-dependent activation of astroglial calcineurin in mouse primary hippocampal cultures,” International Journal of Molecular Sciences, vol. 19, no. 10, 2018. View at Publisher · View at Google Scholar
  • Angela R. Wild, Brooke L. Sinnen, Matthew J. Kennedy, William A. Sather, Mark L. Dell'Acqua, and Philip J. Dittmer, “Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+Channel Ca2+Spike Propagation to the Soma,” Cell Reports, vol. 26, no. 13, pp. 3537–3550.e4, 2019. View at Publisher · View at Google Scholar
  • Patricia E. Ganey, and Sean A. Misek, “Signal Transduction in Disease,” Cellular Signal Transduction in Toxicology and Pharmacology, pp. 73–111, 2019. View at Publisher · View at Google Scholar
  • Piotr Soczewka, Damian Kolakowski, Iwona Smaczynska-de Rooij, Weronika Rzepnikowska, Kathryn R. Ayscough, Joanna Kaminska, and Teresa Zoladek, “Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis,” Disease Models & Mechanisms, vol. 12, no. 1, pp. dmm036830, 2019. View at Publisher · View at Google Scholar