The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents

Table 1

The effects of ovariectomy (ovx) and 17β-estradiol (ovx + E₂) on food intake, body, and organ weight in rats with initial ages of five and ten months. Despite pair-feeding the animals, ovariectomy significantly increased body weight and caused atrophy of uterine tissue without any effects on heart or liver weights.

Parameter	5-month-old			10-month-old
	Sham	Ovx	Ovx + E2	Sham	Ovx	Ovx + E2
Food intake (g/day)	16.38 ± 9.1	16.39 ± 9.8	16.05 ± 9.4	15.65 ± 9.1	15.68 ± 9.8	15.01 ± 9.4
Body weight (g)
Initial	294.00 ± 6.96	293.33 ± 6.65	293.67 ± 4.99	369.40 ± 6.96	370.00 ± 6.65	361.98 ± 4.99
Final	366.40 ± 9.8^a	400.40 ± 9.8^b	350.33 ± 13.38^a	421.80 ± 9.8^A	474.00 ± 10.35^B	404.00 ± 6.91^A
Organ weight (mg)
Uterus	0.618 ± 0.05^a	0.098 ± 0.01^b	0.287 ± 0.03^c	0.733 ± 0.05^A	0.140 ± 0.02^B	0.232 ± 0.01^C
Liver	10.640 ± 0.653	9.362 ± 0.236	8.750 ± 0.617	12.98 ± 1.33	13.22 ± 2.03	10.66 ± 0.06
Heart	1.050 ± 0.057	0.965 ± 0.0293	0.950 ± 0.029	1.186 ± 0.029	1.167 ± 0.035	1.125 ± 0.027

Values are means ± SEM. Values that do not share the same superscript letters in each age category are significantly () different from each other ( per treatment group).