The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents

Table 3

The effects of ovariectomy (ovx) and 17β-estradiol (ovx + E₂) on bone mineral density and bone mineral content of the 4th lumbar and right tibia in rats with initial ages of five and ten months. The mean tibial and vertebral bone mineral density and bone mineral content of ovx rats were significantly lower in comparison with sham rats in both age groups and E₂ administration prevented the bone loss.

Parameters	5-month-old			10-month-old
	Sham	Ovx	Ovx + E2	Sham	Ovx	Ovx + E2
4th lumbar
BMD (g/cm^2)	0.246 ± 0.005	0.195 ± 0.002	0.240 ± 0.005	0.266 ± 0.016	0.207 ± 0.004	0.230 ± 0.004
BMC (g)	0.130 ± 0.007	0.089 ± 0.005	0.128 ± 0.006	0.162 ± 0.017	0.115 ± 0.003	0.127 ± 0.005
Right tibia
BMD (g/cm^2)	0.211 ± 0.003	0.183 ± 0.004	0.209 ± 0.002	0.240 ± 0.009	0.204 ± 0.004	0.218 ± 0.004
BMC (g)	0.314 ± 0.003	0.292 ± 0.007	0.309 ± 0.007	0.375 ± 0.002	0.331 ± 0.009	0.338 ± 0.006

Values are means ± SEM. Values that do not share the same superscript letters in each age category are significantly () different from each other. BMD, bone mineral density; BMC, bone mineral content ( per treatment group).