The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents

Table 5

The effects of ovariectomy (ovx) and 17β-estradiol (ovx + E₂) on blood parameters in rats with initial ages of five and ten months. Ovariectomy significantly lowered serum E₂ and increased B-ALP and CTX in both age groups.

Parameter	5-month-old			10-month-old
	Sham	Ovx	Ovx + E2	Sham	Ovx	Ovx + E2
E2 (ng/mL)	18.50 ± 4.5	7.89 ± 3.8	24.19 ± 3.1	21.07 ± 7.1	8.45 ± 2.1	28.10 ± 4.5
B -ALP (U/L)	24.16 ± 13.51	29.77 ± 8.81	25.10 ± 11.43	20.56 ± 7.75	27.35 ± 9.02	24.01 ± 8.8
CTX (ng/ml)	84.25 ± 9.05	110.22 ± 11.01	90.03 ± 10.03	77.50 ± 9.05	103.95 ± 11.02	82.32 ± 8.01

Values are means ± SEM. Values that do not share the same superscript letters in each age category are significantly () different from each other. CTX, C-telopeptides of type I collagen; B-ALP, bone specific alkaline phosphatase; and E₂, estrogen ( per treatment group).