Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Figure 2

Insulin resistance in young vash1^−/− mice. Fasting blood glucose, fasting plasma insulin, and HOMA-IR are compared between WT and vash1^−/− of young (a) and old (b) male mice. Means ± SDs are shown. The statistical significance of differences was calculated by use of unpaired Student’s -test, and a value of was the criterion for significance. .

(a)

(b)