Table of Contents Author Guidelines Submit a Manuscript
Journal of Aging Research
Volume 2017, Article ID 9851380, 11 pages
https://doi.org/10.1155/2017/9851380
Research Article

Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

1Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
2Department of Diabetes and Metabolism, Graduate School of Medicine, Tokyo University, Tokyo, Japan

Correspondence should be addressed to Yasufumi Sato; pj.ca.ukohot@3b.otas.imufusay

Received 13 December 2016; Revised 30 January 2017; Accepted 16 February 2017; Published 6 March 2017

Academic Editor: Barbara Shukitt-Hale

Copyright © 2017 Eichi Takeda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Kaeberlein, P. S. Rabinovitch, and G. M. Martin, “Healthy aging: the ultimate preventative medicine,” Science, vol. 350, no. 6265, pp. 1191–1193, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. C. López-Otín, M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer, “The hallmarks of aging,” Cell, vol. 153, no. 6, pp. 1194–1217, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S. J. Russell and C. R. Kahn, “Endocrine regulation of ageing,” Nature Reviews Molecular Cell Biology, vol. 8, no. 9, pp. 681–691, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. Kenyon, “The genetics of ageing,” Nature, vol. 464, no. 7288, pp. 504–512, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Tatar, A. Bartke, and A. Antebi, “The endocrine regulation of aging by insulin-like signals,” Science, vol. 299, no. 5611, pp. 1346–1351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. C. E. Riera and A. Dillin, “Tipping the metabolic scales towards increased longevity in mammals,” Nature Cell Biology, vol. 17, no. 3, pp. 196–203, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang, “A C. elegans mutant that lives twice as long as wild type,” Nature, vol. 366, no. 6454, pp. 461–464, 1993. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Tatar, A. Kopelman, D. Epstein, M.-P. Tu, C.-M. Yin, and R. S. Garofalo, “A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function,” Science, vol. 292, no. 5514, pp. 107–110, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Blüher, B. B. Kahn, and C. R. Kahn, “Extended longevity in mice lacking the insulin receptor in adipose tissue,” Science, vol. 299, no. 5606, pp. 572–574, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Cohen and A. Dillin, “The insulin paradox: aging, proteotoxicity and neurodegeneration,” Nature Reviews Neuroscience, vol. 9, no. 10, pp. 759–767, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. C. Kovacic, P. Moreno, V. Hachinski, E. G. Nabel, and V. Fuster, “Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review,” Circulation, vol. 123, no. 15, pp. 1650–1660, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. C. Kovacic, P. Moreno, E. G. Nabel, V. Hachinski, and V. Fuster, “Cellular senescence, vascular disease, and aging: part 2 of a 2-part review: Clinical vascular disease in the elderly,” Circulation, vol. 123, no. 17, pp. 1900–1910, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Sato, “Novel link between inhibition of angiogenesis and tolerance to vascular stress,” Journal of Atherosclerosis and Thrombosis, vol. 22, no. 4, pp. 327–334, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Watanabe, Y. Hasegawa, H. Yamashita et al., “Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis,” Journal of Clinical Investigation, vol. 114, no. 7, pp. 898–907, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Miyashita, T. Watanabe, H. Hayashi et al., “Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1,” PLoS ONE, vol. 7, no. 10, Article ID e46459, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Hinamoto, Y. Maeshima, H. Yamasaki et al., “Exacerbation of diabetic renal alterations in mice lacking vasohibin-1,” PLoS ONE, vol. 9, no. 9, Article ID 0107934, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Takeda, Y. Suzuki, and Y. Sato, “Age-associated downregulation of vasohibin-1 in vascular endothelial cells,” Aging Cell, vol. 15, no. 5, pp. 885–892, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Kimura, H. Miyashita, Y. Suzuki et al., “Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis,” Blood, vol. 113, no. 19, pp. 4810–4818, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Zhang and F. Liu, “Tissue-specific insulin signaling in the regulation of metabolism and aging,” IUBMB Life, vol. 66, no. 7, pp. 485–495, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Martins, G. J. Lithgow, and W. Link, “Long live FOXO: unraveling the role of FOXO proteins in aging and longevity,” Aging Cell, vol. 15, no. 2, pp. 196–207, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Tabata, T. Kadomatsu, S. Fukuhara et al., “Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance,” Cell Metabolism, vol. 10, no. 3, pp. 178–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Villaret, J. Galitzky, P. Decaunes et al., “Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence,” Diabetes, vol. 59, no. 11, pp. 2755–2763, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Hasegawa, T. Saito, T. Ogihara et al., “Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans,” Circulation, vol. 125, no. 9, pp. 1122–1133, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. N. J. Pillon, P. M. Azizi, Y. E. Li et al., “Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis,” American Journal of Physiology—Endocrinology and Metabolism, vol. 309, no. 1, pp. E35–E44, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. X. Sun, J. Lin, Y. Zhang et al., “MicroRNA-181b improves glucose homeostasis and insulin sensitivity by regulating endothelial function in white adipose tissue,” Circulation Research, vol. 118, no. 5, pp. 810–821, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Elias, S. Franckhauser, and F. Bosch, “New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance,” Adipocyte, vol. 2, no. 2, pp. 109–112, 2014. View at Publisher · View at Google Scholar
  27. H.-K. Sung, K.-O. Doh, J. E. Son et al., “Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis,” Cell Metabolism, vol. 17, no. 1, pp. 61–72, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Honek, T. Seki, H. Iwamoto et al., “Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 41, pp. 14906–14911, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. M. R. Robciuc, R. Kivelä, I. M. Williams et al., “VEGFB/VEGFR1-induced expansion of adipose vasculature counteracts obesity and related metabolic complications,” Cell Metabolism, vol. 23, no. 4, pp. 712–724, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Bartke, “Early life events can shape aging and longevity,” Current Aging Science, vol. 8, no. 1, pp. 11–13, 2015. View at Publisher · View at Google Scholar · View at Scopus