The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women

Table 2

APOE genotype and allele as predictors of all-cause mortality.

	Unadjusted	Model 1	Model 2	Model 3	Model 4
Apolipoprotein E genotype
APOE ε3/3	1	1	1	1	1
APOE ε2/2, 2/3	0.80 (0.34–1.80)	0.73 (0.32–1.65)	0.73 (0.32–1.68)	0.75 (0.32–1.74)	0.73 (0.31–1.71)
APOE ε3/4, 4/4	2.38 (1.33–4.26)	2.34 (1.30–4.36)	2.53 (1.35–4.73)	2.56 (1.33–4.94)	2.61 (1.33–5.14)
Apolipoprotein E allele
APOE ε4 noncarrier	1	1	1	1	1
APOE ε4 carrier	1.99 (1.17–3.38)	2.20 (1.25–3.86)	2.26 (1.24–4.13)	2.21 (1.20–4.09)	2.76 (1.42–5.37)

Model 1: adjusted for age, sex, education, and marital status; model 2: model 1 plus levels of triglyceride, body mass index, bone mineral density, and diastolic blood pressure; model 3: model 2 plus Geriatric Depression Scale and the Modified Mini-Mental State Examination scores; model 4: model 3 plus incident medical conditions occurring during follow-up (cancers, nonvertebral or vertebral fractures, diabetes, ischemic heart disease, and cerebrovascular disease).