Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy
IGF-1 downregulated cyclic-dependent kinase inhibitors p16 and p21. P5 and P20 Con SMC and IGF-1R-KO SMC were exposed to 10 ng/ml IGF-1 for 12 hours, and p16 and β-actin levels (a, b) or p21 and β-actin levels (c, d) were quantified by immunoblotting. for P20 SMC vs. P5 SMC. # vs. no IGF-1.
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