Table of Contents
Journal of Blood Transfusion
Volume 2016, Article ID 4860284, 28 pages
http://dx.doi.org/10.1155/2016/4860284
Review Article

Quality Assessment of Established and Emerging Blood Components for Transfusion

1Centre for Innovation, Canadian Blood Services, Edmonton, AB, Canada
2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
3Research and Development, Australian Red Cross Blood Service, Sydney, NSW, Australia
4Centre for Innovation, Canadian Blood Services, Hamilton, ON, Canada
5Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada

Received 31 August 2016; Accepted 2 November 2016

Academic Editor: Maria Rios

Copyright © 2016 Jason P. Acker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Arya, G. S. Wander, and P. Gupta, “Blood component therapy: which, when and how much,” Journal of Anaesthesiology Clinical Pharmacology, vol. 27, no. 2, pp. 278–284, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. R. R. Vassallo and S. Murphy, “A critical comparison of platelet preparation methods,” Current Opinion in Hematology, vol. 13, no. 5, pp. 323–330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Blajchman, “The clinical benefits of the leukoreduction of blood products,” Journal of Trauma—Injury, Infection and Critical Care, vol. 60, no. 6, pp. S83–S88, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Zielinski, D. H. Jenkins, J. D. Hughes, K. S. W. Badjie, and J. R. Stubbs, “Back to the future: the renaissance of whole-blood transfusions for massively hemorrhaging patients,” Surgery (United States), vol. 155, no. 5, pp. 883–886, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. S. F. O'Brien, Q.-L. Yi, W. Fan, V. Scalia, M. A. Fearon, and J.-P. Allain, “Current incidence and residual risk of HIV, HBV and HCV at Canadian Blood Services,” Vox Sanguinis, vol. 103, no. 1, pp. 83–86, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. E. S. Cooper, A. W. Bracey, A. E. Horvath, J. N. Shanberge, T. L. Simon, and D. H. Yawn, “Practice parameter for the use of fresh-frozen plasma, cryoprecipitate, and platelets. Fresh-Frozen Plasma, Cryoprecipitate, and Platelets Administration Practice Guidelines Development Task Force of the College of American Pathologists,” The Journal of the American Medical Association, vol. 271, no. 10, pp. 777–781, 1994. View at Publisher · View at Google Scholar
  7. “Guidelines for red blood cell and plasma transfusion for adults and children,” Canadian Medical Association Journal, vol. 156, no. 11, supplement, pp. S1–S24, 1997.
  8. “Expert Working Group Guidelines for red blood cell and plasma transfusion for adults and children,” Canadian Medical Association Journal, vol. 156, no. 11, pp. S1–S24, 1997.
  9. British Committee for Standards in Haematology, “Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant,” British Journal of Haematology, vol. 126, no. 1, pp. 11–28, 2004. View at Publisher · View at Google Scholar
  10. M. E. Steiner, P. M. Ness, S. F. Assmann et al., “Effects of red-cell storage duration on patients undergoing cardiac surgery,” The New England Journal of Medicine, vol. 372, no. 15, pp. 1419–1429, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. AABB Standards for Blood Banks and Transfusion Services, AABB Press, Bethesda, Md, USA, 30th edition, 2016.
  12. G. Liumbruno, F. Bennardello, A. Lattanzio, P. Piccoli, and G. Rossetti, “Recommendations for the transfusion of plasma and platelets,” Blood Transfusion, vol. 7, no. 2, pp. 132–150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. B. J. Hunt, “Bleeding and coagulopathies in critical care,” The New England Journal of Medicine, vol. 370, no. 9, pp. 847–859, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. A. J. Gale, “Continuing education course #2: current understanding of hemostasis,” Toxicologic Pathology, vol. 39, no. 1, pp. 273–280, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Yang, S. Stanworth, S. Hopewell, C. Doree, and M. Murphy, “Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials (CME),” Transfusion, vol. 52, no. 8, pp. 1673–1686, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. J. Stanworth, S. J. Brunskill, C. J. Hyde, D. B. L. McClelland, and M. F. Murphy, “Is fresh frozen plasma clinically effective? a systematic review of randomized controlled trials,” British Journal of Haematology, vol. 126, no. 1, pp. 139–152, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. M. H. Murad, J. R. Stubbs, M. J. Gandhi et al., “The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis,” Transfusion, vol. 50, no. 6, pp. 1370–1383, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. G. A. Rock, K. H. Shumak, N. A. Buskard et al., “Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group,” The New England Journal of Medicine, vol. 325, no. 6, pp. 393–397, 1991. View at Publisher · View at Google Scholar
  19. G. Rock, D. Anderson, W. Clark et al., “Does cryosupernatant plasma improve outcome in thrombotic thrombocytopenic purpura? No answer yet,” British Journal of Haematology, vol. 129, no. 1, pp. 79–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. S. J. Brunskill, A. Tusold, S. Benjamin, S. J. Stanworth, and M. F. Murphy, “A systematic review of randomized controlled trials for plasma exchange in the treatment of thrombotic thrombocytopenic purpura,” Transfusion Medicine, vol. 17, no. 1, pp. 17–35, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. L. Callum and S. Rizoli, “Plasma transfusion for patients with severe hemorrhage: what is the evidence?” Transfusion, vol. 52, supplement 1, pp. 30S–37S, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. J. B. Holcomb, B. C. Tilley, S. Baraniuk et al., “Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial,” Journal of the American Medical Association, vol. 313, no. 5, pp. 471–482, 2015. View at Google Scholar
  23. A. Kovács and A. Guttman, “Medicinal chemistry meets proteomics: fractionation of the human plasma proteome,” Current Medicinal Chemistry, vol. 20, no. 4, pp. 483–490, 2013. View at Google Scholar · View at Scopus
  24. R. Pieper, C. L. Gatlin, A. J. Makusky et al., “The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins,” Proteomics, vol. 3, no. 7, pp. 1345–1364, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. E. J. Favaloro, S. Soltani, J. McDonald, E. Grezchnik, and L. Easton, “Cross-laboratory audit of normal reference ranges and assessment of ABO blood group, gender and age on detected levels of plasma coagulation factors,” Blood Coagulation and Fibrinolysis, vol. 16, no. 8, pp. 597–605, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Franchini and G. Lippi, “Fibrinogen replacement therapy: a critical review of the literature,” Blood Transfusion, vol. 10, no. 1, pp. 23–27, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Palla, F. Peyvandi, and A. D. Shapiro, “Rare bleeding disorders: diagnosis and treatment,” Blood, vol. 125, no. 13, pp. 2052–2061, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. J. B. Lefkowitz, A. Weller, R. Nuss, P. J. Santiago-Borrero, D. L. Brown, and I. R. Ortiz, “A common mutation, Arg457→Gln, links prothrombin deficiencies in the Puerto Rican population,” Journal of Thrombosis and Haemostasis, vol. 1, no. 11, pp. 2381–2388, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. P. M. Aggeler, “Physiological basis for transfusion therapy in hemorrhagic disorders: a critical review,” Transfusion, vol. 1, pp. 71–86, 1961. View at Publisher · View at Google Scholar · View at Scopus
  30. D. J. Murray, J. Olson, R. Strauss, and J. H. Tinker, “Coagulation changes during packed red cell replacement of major blood loss,” Anesthesiology, vol. 69, no. 6, pp. 839–845, 1988. View at Publisher · View at Google Scholar · View at Scopus
  31. S. T. Hiippala, G. J. Myllyla, and E. M. Vahtera, “Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates,” Anesthesia & Analgesia, vol. 81, no. 2, pp. 360–365, 1995. View at Publisher · View at Google Scholar · View at Scopus
  32. W. N. Erber, “Massive blood transfusion in the elective surgical setting,” Transfusion and Apheresis Science, vol. 27, no. 1, pp. 83–92, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Tinmouth, “Assessing the rationale and effectiveness of frozen plasma transfusions: an evidence-based review,” Hematology/Oncology Clinics of North America, vol. 30, no. 3, pp. 561–572, 2016. View at Publisher · View at Google Scholar
  34. R. B. Counts, C. Haisch, T. L. Simon, N. G. Maxwell, D. M. Heimbach, and C. J. Carrico, “Hemostasis in massively transfused trauma patients,” Annals of Surgery, vol. 190, no. 1, pp. 91–99, 1979. View at Publisher · View at Google Scholar · View at Scopus
  35. R. M. Kakaiya, E. E. Morse, and S. Panek, “Labile coagulation factors in thawed fresh frozen plasma prepared by two methods,” Vox Sanguinis, vol. 46, no. 1, pp. 44–46, 1984. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Cardigan, P. F. Van Der Meer, C. Pergande et al., “Coagulation factor content of plasma produced from whole blood stored for 24 hours at ambient temperature: results from an international multicenter BEST Collaborative study,” Transfusion, vol. 51, supplement 1, pp. 50S–57S, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. W. P. Sheffield, V. Bhakta, C. Mastronardi, S. Ramirez-Arcos, D. Howe, and C. Jenkins, “Changes in coagulation factor activity and content of di(2-ethylhexyl)phthalate in frozen plasma units during refrigerated storage for up to five days after thawing,” Transfusion, vol. 52, no. 3, pp. 493–502, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. N. A. Orlova, S. V. Kovnir, I. I. Vorobiev, A. G. Gabibov, and A. I. Vorobiev, “Blood clotting factor VIII: from evolution to therapy,” Acta Naturae, vol. 5, no. 2, pp. 19–39, 2013. View at Google Scholar · View at Scopus
  39. N. Matijevic, Y.-W. Wang, B. A. Cotton et al., “Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma,” Journal of Trauma and Acute Care Surgery, vol. 74, no. 1, pp. 84–91, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. A. E. Pusateri, M. B. Given, M. A. Schreiber et al., “Dried plasma: state of the science and recent developments,” Transfusion, vol. 56, supplement 2, pp. S128–S139, 2016. View at Publisher · View at Google Scholar
  41. Circular of Information for the Use of Human Blood and Blood Components, AABB/American Red Cross/America’s Blood Centers/The Armed Services Blood Program, Puget Sound , Wash, USA, 2013.
  42. A. F. Eder and M. A. Sebok, “Plasma components: FFP, FP24, and thawed plasma,” Immunohematology, vol. 23, no. 4, pp. 150–157, 2007. View at Google Scholar · View at Scopus
  43. Blood Component Information Circular of Information, Australian Red Cross Blood Transfusion Service, Melbourne, Australia, 2015.
  44. M. Franchini, E. J. Favaloro, and G. Lippi, “Mild hemophilia A,” Journal of Thrombosis and Haemostasis, vol. 8, no. 3, pp. 421–432, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. J. O'Donnell, E. G. D. Tuddenham, R. Manning, G. Kemball-Cook, D. Johnson, and M. Laffan, “High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction,” Thrombosis and Haemostasis, vol. 77, no. 5, pp. 825–828, 1997. View at Google Scholar · View at Scopus
  46. B. Nascimento, L. T. Goodnough, and J. H. Levy, “Cryoprecipitate therapy,” British Journal of Anaesthesia, vol. 113, no. 6, pp. 922–934, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. D. F. O'Shaughnessy, C. Atterbury, P. B. Maggs et al., “Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant,” British Journal of Haematology, vol. 126, no. 1, pp. 11–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. Circular of Information, Canadian Blood Services, Ottawa, Canada, 2016.
  49. A. H. Kamal, A. Tefferi, and R. K. Pruthi, “How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults,” Mayo Clinic Proceedings, vol. 82, no. 7, pp. 864–873, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. J. B. Segal and W. H. Dzik, “Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review,” Transfusion, vol. 45, no. 9, pp. 1413–1425, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. M. D. Lancé, “A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis,” Thrombosis Journal, vol. 13, article 1, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. G. A. Hans and M. W. Besser, “The place of viscoelastic testing in clinical practice,” British Journal of Haematology, vol. 173, no. 1, pp. 37–48, 2016. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Solomon, L. M. Asmis, and D. R. Spahn, “Is viscoelastic coagulation monitoring with ROTEM or TEG validated?” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 76, no. 6, pp. 503–507, 2016. View at Publisher · View at Google Scholar
  54. R. Cardigan, J. Sutherland, M. Garwood et al., “The effect of leucocyte depletion on the quality of fresh-frozen plasma,” British Journal of Haematology, vol. 114, no. 1, pp. 233–240, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. M. Heiden, U. Salge, R. Henschler et al., “Plasma quality after whole-blood filtration depends on storage temperature and filter type,” Transfusion Medicine, vol. 14, no. 4, pp. 297–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. K. S.-K. Chan and R. L. Sparrow, “Microparticle profile and procoagulant activity of fresh-frozen plasma is affected by whole blood leukoreduction rather than 24-hour room temperature hold,” Transfusion, vol. 54, no. 8, pp. 1935–1944, 2014. View at Publisher · View at Google Scholar · View at Scopus
  57. P. F. van der Meer and D. de Korte, “The effect of holding times of whole blood and its components during processing on in vitro and in vivo quality,” Transfusion Medicine Reviews, vol. 29, no. 1, pp. 24–34, 2015. View at Publisher · View at Google Scholar · View at Scopus
  58. R. N. I. Pietersz, D. de Korte, H. W. Reesink, W. J. A. Dekker, A. van den Ende, and J. A. Loos, “Storage of whole blood for up to 24 hours at ambient temperature prior to component preparation,” Vox Sanguinis, vol. 56, no. 3, pp. 145–150, 1989. View at Publisher · View at Google Scholar · View at Scopus
  59. E. M. O'Neill, J. Rowley, M. Hansson-Wicher, S. McCarter, G. Ragno, and C. R. Valeri, “Effect of 24-hour whole-blood storage on plasma clotting factors,” Transfusion, vol. 39, no. 5, pp. 488–491, 1999. View at Publisher · View at Google Scholar · View at Scopus
  60. C. Wilsher, M. Garwood, J. Sutherland, C. Turner, and R. Cardigan, “The effect of storing whole blood at 22°C for up to 24 hours with and without rapid cooling on the quality of red cell concentrates and fresh-frozen plasma,” Transfusion, vol. 48, no. 11, pp. 2338–2347, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. P. F. van der Meer and D. de Korte, “Active cooling of whole blood to room temperature improves blood component quality,” Transfusion, vol. 51, no. 2, pp. 357–362, 2011. View at Publisher · View at Google Scholar · View at Scopus
  62. L. Thibault, A. Beauséjour, M. J. de Grandmont, R. Lemieux, and J.-F. Leblanc, “Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method,” Transfusion, vol. 46, no. 8, pp. 1292–1299, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. K. Serrano, K. Scammell, S. Weiss et al., “Plasma and cryoprecipitate manufactured from whole blood held overnight at room temperature meet quality standards,” Transfusion, vol. 50, no. 2, pp. 344–353, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Shinar, S. Etlin, O. Frenkel, and V. Yahalom, “The implementation of rapid cooling and overnight hold of whole blood at ambient temperature before processing into components in Israel,” Transfusion, vol. 51, supplement 1, pp. 58S–64S, 2011. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Wang, T. Wang, Y. Fan et al., “A comparison study of the blood component quality of whole blood held overnight at 4°C or room temperature,” Journal of Blood Transfusion, vol. 2013, Article ID 523539, 7 pages, 2013. View at Publisher · View at Google Scholar
  66. L. J. Dumont, J. A. Cancelas, L. A. Maes et al., “The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collection,” Transfusion, vol. 55, no. 3, pp. 476–484, 2015. View at Publisher · View at Google Scholar · View at Scopus
  67. D. Triulzi, J. Gottschall, E. Murphy et al., “A multicenter study of plasma use in the United States,” Transfusion, vol. 55, no. 6, pp. 1313–1319, 2015. View at Publisher · View at Google Scholar · View at Scopus
  68. G. Carlebjork, M. Blomback, and P. Pihlstedt, “Freezing of plasma and recovery of factor VIII,” Transfusion, vol. 26, no. 2, pp. 159–162, 1986. View at Publisher · View at Google Scholar · View at Scopus
  69. A.-M. Swärd-Nilsson, P.-O. Persson, U. Johnson, and S. Lethagen, “Factors influencing factor VIII activity in frozen plasma,” Vox Sanguinis, vol. 90, no. 1, pp. 33–39, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. S. Runkel, H. Haubelt, W. Hitzler, and P. Hellstern, “The quality of plasma collected by automated apheresis and of recovered plasma from leukodepleted whole blood,” Transfusion, vol. 45, no. 3, pp. 427–432, 2005. View at Publisher · View at Google Scholar · View at Scopus
  71. D. J. Triulzi, “AABB contributions to plasma safety,” Transfusion, vol. 52, no. 1, pp. 5S–8S, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Godier, C.-M. Samama, and S. Susen, “Plasma/platelets/red blood cell ratio in the management of the bleeding traumatized patient: does it matter?” Current Opinion in Anaesthesiology, vol. 25, no. 2, pp. 242–247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. K. A. Downes, E. Wilson, R. Yomtovian, and R. Sarode, “Serial measurement of clotting factors in thawed plasma stored for 5 days,” Transfusion, vol. 41, no. 4, p. 570, 2001. View at Publisher · View at Google Scholar · View at Scopus
  74. E. Scott, K. Puca, J. Heraly, J. Gottschall, and K. Friedman, “Evaluation and comparison of coagulation factor activity in fresh-frozen plasma and 24-hour plasma at thaw and after 120 hours of 1 to 6°C storage,” Transfusion, vol. 49, no. 8, pp. 1584–1591, 2009. View at Publisher · View at Google Scholar · View at Scopus
  75. R. S. Sidhu, T. Le, B. Brimhall, and H. Thompson, “Study of coagulation factor activities in apheresed thawed fresh frozen plasma at 1–6°C for five days,” Journal of Clinical Apheresis, vol. 21, no. 4, pp. 224–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  76. C. Von Heymann, M. K. Keller, C. Spies et al., “Activity of clotting factors in fresh-frozen plasma during storage at 4°C over 6 days,” Transfusion, vol. 49, no. 5, pp. 913–920, 2009. View at Publisher · View at Google Scholar · View at Scopus
  77. P. Cookson, S. Thomas, S. Marschner, R. Goodrich, and R. Cardigan, “In vitro quality of single-donor platelets treated with riboflavin and ultraviolet light and stored in platelet storage medium for up to 8 days,” Transfusion, vol. 52, no. 5, pp. 983–994, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. R. Cardigan and L. Green, “Thawed and liquid plasma—what do we know?” Vox Sanguinis, vol. 109, no. 1, pp. 1–10, 2015. View at Publisher · View at Google Scholar · View at Scopus
  79. P. Hellstern, “Solvent/detergent-treated plasma: composition, efficacy, and safety,” Current Opinion in Hematology, vol. 11, no. 5, pp. 346–350, 2004. View at Publisher · View at Google Scholar · View at Scopus
  80. P. F. Lindholm, K. Annen, and G. Ramsey, “Approaches to minimize infection risk in blood banking and transfusion practice,” Infectious Disorders—Drug Targets, vol. 11, no. 1, pp. 45–56, 2011. View at Publisher · View at Google Scholar · View at Scopus
  81. B. Horowitz, R. Bonomo, A. M. Prince, S. N. Chin, B. Brotman, and R. W. Shulman, “Solvent/detergent-treated plasma: a virus-inactivated substitute for fresh frozen plasma,” Blood, vol. 79, no. 3, pp. 826–831, 1992. View at Google Scholar · View at Scopus
  82. T.-E. Svae, W. Frenzel, A. Heger, and J. Römisch, “Quality differences between solvent/detergent plasmas and fresh-frozen plasma,” Transfusion Medicine, vol. 17, no. 4, pp. 318–321, 2007. View at Publisher · View at Google Scholar · View at Scopus
  83. A. S. Lawrie, L. Green, M. T. Canciani et al., “The effect of prion reduction in solvent/detergent-treated plasma on haemostatic variables,” Vox Sanguinis, vol. 99, no. 3, pp. 232–238, 2010. View at Publisher · View at Google Scholar · View at Scopus
  84. J.-C. Osselaer, C. Debry, M. Goffaux et al., “Coagulation function in fresh-frozen plasma prepared with two photochemical treatment methods: methylene blue and amotosalen,” Transfusion, vol. 48, no. 1, pp. 108–117, 2008. View at Publisher · View at Google Scholar · View at Scopus
  85. L. Backholer, M. Wiltshire, S. Proffitt, P. Cookson, and R. Cardigan, “Paired comparison of methylene blue- and amotosalen-treated plasma and cryoprecipitate,” Vox Sanguinis, vol. 110, no. 4, pp. 352–361, 2016. View at Publisher · View at Google Scholar · View at Scopus
  86. R. Cardigan, K. Philpot, P. Cookson, and R. Luddington, “Thrombin generation and clot formation in methylene blue-treated plasma and cryoprecipitate,” Transfusion, vol. 49, no. 4, pp. 696–703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. T. Hubbard, L. Backholer, M. Wiltshire, R. Cardigan, and R. A. S. Ariëns, “Effects of riboflavin and amotosalen photoactivation systems for pathogen inactivation of fresh-frozen plasma on fibrin clot structure,” Transfusion, vol. 56, no. 1, pp. 41–48, 2016. View at Publisher · View at Google Scholar · View at Scopus
  88. V. S. Hornsey, O. Drummond, A. Morrison, L. McMillan, I. R. MacGregor, and C. V. Prowse, “Pathogen reduction of fresh plasma using riboflavin and ultraviolet light: effects on plasma coagulation proteins,” Transfusion, vol. 49, no. 10, pp. 2167–2172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  89. K. Izutsu, “Stabilization of therapeutic proteins in aqueous solutions and freeze-dried solids: an overview,” Methods in Molecular Biology, vol. 1129, pp. 435–441, 2014. View at Publisher · View at Google Scholar
  90. A. Sailliol, C. Martinaud, A. P. Cap et al., “The evolving role of lyophilized plasma in remote damage control resuscitation in the French Armed Forces Health Service,” Transfusion, vol. 53, supplement 1, pp. 65S–71S, 2013. View at Publisher · View at Google Scholar · View at Scopus
  91. J. Bux, D. Dickhörner, and E. Scheel, “Quality of freeze-dried (lyophilized) quarantined single-donor plasma,” Transfusion, vol. 53, no. 12, pp. 3203–3209, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. C. Martinaud, C. Civadier, S. Ausset, C. Verret, A.-V. Deshayes, and A. Sailliol, “In vitro hemostatic properties of french lyophilized plasma,” Anesthesiology, vol. 117, no. 2, pp. 339–346, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. T. Burnouf, “Modern plasma fractionation,” Transfusion Medicine Reviews, vol. 21, no. 2, pp. 101–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  94. M. Radosevich and T. Burnouf, “Intravenous immunoglobulin G: trends in production methods, quality control and quality assurance,” Vox Sanguinis, vol. 98, no. 1, pp. 12–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  95. J. Curnow, L. Pasalic, and E. J. Favaloro, “Treatment of von willebrand disease,” Seminars in Thrombosis and Hemostasis, vol. 42, no. 2, pp. 133–146, 2016. View at Publisher · View at Google Scholar · View at Scopus
  96. A. Casini, P. de Moerloose, and M. Neerman-Arbez, “Clinical features and management of congenital fibrinogen deficiencies,” Seminars in Thrombosis and Hemostasis, vol. 42, no. 4, pp. 366–374, 2016. View at Google Scholar
  97. J. N. Goldstein, M. A. Refaai, T. J. Milling Jr. et al., “Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial,” The Lancet, vol. 385, no. 9982, pp. 2077–2087, 2015. View at Publisher · View at Google Scholar · View at Scopus
  98. C. Tersteeg, A. Schiviz, S. F. De Meyer et al., “Potential for recombinant ADAMTS13 as an effective therapy for acquired thrombotic thrombocytopenic purpura,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, no. 11, pp. 2336–2342, 2015. View at Publisher · View at Google Scholar · View at Scopus
  99. M. P. Zeller, K. S. Al-Habsi, M. Golder, G. M. Walsh, and W. P. Sheffield, “Plasma and plasma protein product transfusion: a canadian blood services centre for innovation symposium,” Transfusion Medicine Reviews, vol. 29, no. 3, pp. 181–194, 2015. View at Publisher · View at Google Scholar · View at Scopus
  100. B. Whitaker, S. Rajbhandary, S. Kleinman, A. Harris, and N. Kamani, “Trends in United States blood collection and transfusion: results from the 2013 AABB Blood Collection, Utilization, and Patient Blood Management Survey,” Transfusion, vol. 56, no. 9, pp. 2173–2183, 2016. View at Publisher · View at Google Scholar
  101. A. Tinmouth, T. Thompson, D. M. Arnold et al., “Utilization of frozen plasma in Ontario: a provincewide audit reveals a high rate of inappropriate transfusions,” Transfusion, vol. 53, no. 10, pp. 2222–2229, 2013. View at Publisher · View at Google Scholar · View at Scopus
  102. A. W. Shih, E. Kolesar, S. Ning, N. Manning, D. M. Arnold, and M. A. Crowther, “Evaluation of the appropriateness of frozen plasma usage after introduction of prothrombin complex concentrates: A retrospective study,” Vox Sanguinis, vol. 108, no. 3, pp. 274–280, 2015. View at Publisher · View at Google Scholar · View at Scopus
  103. C.-H. Hui, I. Williams, and K. Davis, “Clinical audit of the use of fresh-frozen plasma and platelets in a tertiary teaching hospital and the impact of a new transfusion request form,” Internal Medicine Journal, vol. 35, no. 5, pp. 283–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  104. S. Pybus, A. MacCormac, A. Houghton, V. Martlew, and J. Thachil, “Inappropriateness of fresh frozen plasma for abnormal coagulation tests,” Journal of the Royal College of Physicians of Edinburgh, vol. 42, no. 4, pp. 294–300, 2013. View at Publisher · View at Google Scholar · View at Scopus
  105. S. J. Stanworth, L. J. Estcourt, G. Powter et al., “A no-prophylaxis platelet-transfusion strategy for hematologic cancers,” The New England Journal of Medicine, vol. 368, no. 19, pp. 1771–1780, 2013. View at Publisher · View at Google Scholar · View at Scopus
  106. R. M. Kaufman, B. Djulbegovic, T. Gernsheimer et al., “Platelet transfusion: a clinical practice guideline from the AABB,” Annals of Internal Medicine, vol. 162, no. 3, pp. 205–213, 2015. View at Publisher · View at Google Scholar · View at Scopus
  107. M. J. Cohen and S. A. Christie, “New understandings of post injury coagulation and resuscitation,” International Journal of Surgery, vol. 33, pp. 242–245, 2016. View at Publisher · View at Google Scholar
  108. R. N. I. Pietersz, H. W. Reesink, S. Panzer et al., “Bacterial contamination in platelet concentrates,” Vox Sanguinis, vol. 106, no. 3, pp. 256–283, 2014. View at Publisher · View at Google Scholar · View at Scopus
  109. P. F. van der Meer, “PAS or plasma for storage of platelets? A concise review,” Transfusion Medicine, vol. 26, no. 5, pp. 339–342, 2016. View at Publisher · View at Google Scholar
  110. J. N. Thon, P. Schubert, and D. V. Devine, “Platelet Storage Lesion: a new understanding from a proteomic perspective,” Transfusion Medicine Reviews, vol. 22, no. 4, pp. 268–279, 2008. View at Publisher · View at Google Scholar · View at Scopus
  111. B. G. Solheim, O. Flesland, J. Seghatchian, and F. Brosstad, “Clinical implications of red blood cell and platelet storage lesions: an overview,” Transfusion and Apheresis Science, vol. 31, no. 3, pp. 185–189, 2004. View at Publisher · View at Google Scholar · View at Scopus
  112. C. Saunders, G. Rowe, K. Wilkins, and P. Collins, “Impact of glucose and acetate on the characteristics of the platelet storage lesion in platelets suspended in additive solutions with minimal plasma,” Vox Sanguinis, vol. 105, no. 1, pp. 1–10, 2013. View at Publisher · View at Google Scholar · View at Scopus
  113. K. M. Reddoch, H. F. Pidcoke, R. K. Montgomery et al., “Hemostatic function of apheresis platelets stored at 4°C and 22°C,” Shock, vol. 41, no. 1, pp. 54–61, 2014. View at Publisher · View at Google Scholar · View at Scopus
  114. L. Johnson, S. Tan, B. Wood, A. Davis, and D. C. Marks, “Refrigeration and cryopreservation of platelets differentially affect platelet metabolism and function: a comparison with conventional platelet storage conditions,” Transfusion, vol. 56, no. 7, pp. 1807–1818, 2016. View at Publisher · View at Google Scholar
  115. L. Johnson, C. P. Coorey, and D. C. Marks, “The hemostatic activity of cryopreserved platelets is mediated by phosphatidylserine-expressing platelets and platelet microparticles,” Transfusion, vol. 54, no. 8, pp. 1917–1926, 2014. View at Publisher · View at Google Scholar · View at Scopus
  116. F. Bertolini and S. Murphy, “A multicenter inspection of the swirling phenomenon in platelet concentrates prepared in routine practice,” Transfusion, vol. 36, no. 2, pp. 128–132, 1996. View at Publisher · View at Google Scholar · View at Scopus
  117. T. VandenBroeke, L. J. Dumont, S. Hunter et al., “Platelet storage solution effects on the accuracy of laboratory tests for platelet function: A Multi-laboratory study,” Vox Sanguinis, vol. 86, no. 3, pp. 183–188, 2004. View at Publisher · View at Google Scholar · View at Scopus
  118. B. K. Kim and M. G. Baldini, “The platelet response to hypotonic shock. Its value as an indicator of platelet viability after storage,” Transfusion, vol. 14, no. 2, pp. 130–138, 1974. View at Publisher · View at Google Scholar · View at Scopus
  119. S. Holme, G. Moroff, and S. Murphy, “A multi-laboratory evaluation of in vitro platelet assays: the tests for extent of shape change and response to hypotonic shock. Biomedical Excellence for Safer Transfusion Working Party of the International Society of Blood Transfusion,” Transfusion, vol. 38, no. 1, pp. 31–40, 1998. View at Publisher · View at Google Scholar · View at Scopus
  120. P. Järemo, “Some correlations between light transmission changes and some commonly used in vitro assays for the assessment of platelet concentrates,” European Journal of Haematology, vol. 58, no. 3, pp. 181–185, 1997. View at Google Scholar · View at Scopus
  121. E. M. Huang and T. C. Detwiler, “Characteristics of the synergistic actions of platelet agonists,” Blood, vol. 57, no. 4, pp. 685–691, 1981. View at Google Scholar · View at Scopus
  122. L. Johnson, K. M. Winter, T. Hartkopf-Theis, S. Reid, M. Kwok, and D. C. Marks, “Evaluation of the automated collection and extended storage of apheresis platelets in additive solution,” Transfusion, vol. 52, no. 3, pp. 503–509, 2012. View at Publisher · View at Google Scholar · View at Scopus
  123. V. S. Hornsey, K. McColl, O. Drummond et al., “Extended storage of platelets in SSP+ platelet additive solution,” Vox Sanguinis, vol. 91, no. 1, pp. 41–46, 2006. View at Publisher · View at Google Scholar · View at Scopus
  124. J. W. N. Akkerman, “Regulation of carbohydrate metabolism in platelets. A review,” Thrombosis and Haemostasis, vol. 39, no. 3, pp. 712–724, 1978. View at Google Scholar · View at Scopus
  125. J. G. Zhang, C. J. Carter, B. Culibrk et al., “Buffy-coat platelet variables and metabolism during storage in additive solutions or plasma,” Transfusion, vol. 48, no. 5, pp. 847–856, 2008. View at Publisher · View at Google Scholar · View at Scopus
  126. G. Moroff, J. Kurtz, S. Seetharaman et al., “Comparative in vitro evaluation of apheresis platelets stored with 100% plasma or 65% platelet additive solution III/35% plasma and including periods without agitation under simulated shipping conditions,” Transfusion, vol. 52, no. 4, pp. 834–843, 2012. View at Publisher · View at Google Scholar · View at Scopus
  127. L. J. Dumont and T. VandenBroeke, “Seven-day storage of apheresis platelets: report of an in vitro study,” Transfusion, vol. 43, no. 2, pp. 143–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  128. D. W. C. Dekkers, I. M. De Cuyper, P. F. van der Meer, A. J. Verhoeven, and D. De Korte, “Influence of pH on stored human platelets,” Transfusion, vol. 47, no. 10, pp. 1889–1895, 2007. View at Publisher · View at Google Scholar · View at Scopus
  129. P. Metcalfe, L. M. Williamson, C. P. M. Reutellngsperger, I. Swann, W. H. Ouwehand, and A. H. Goodall, “Activation during preparation of therapeutic platelets affects deterioration during storage: a comparative flow cytometric study of different production methods,” British Journal of Haematology, vol. 98, no. 1, pp. 86–95, 1997. View at Publisher · View at Google Scholar · View at Scopus
  130. A.-M. Albanyan, P. Harrison, and M. F. Murphy, “Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 days,” Transfusion, vol. 49, no. 1, pp. 108–117, 2009. View at Publisher · View at Google Scholar · View at Scopus
  131. F. Cognasse, F. Boussoulade, P. Chavarin et al., “Release of potential immunomodulatory factors during platelet storage,” Transfusion, vol. 46, no. 7, pp. 1184–1189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  132. S. M. Picker, “In-vitro assessment of platelet function,” Transfusion and Apheresis Science, vol. 44, no. 3, pp. 305–319, 2011. View at Publisher · View at Google Scholar · View at Scopus
  133. G. C. Leitner, J. List, M. Horvath, B. Eichelberger, S. Panzer, and P. Jilma-Stohlawetz, “Additive solutions differentially affect metabolic and functional parameters of platelet concentrates,” Vox Sanguinis, vol. 110, no. 1, pp. 20–26, 2016. View at Publisher · View at Google Scholar · View at Scopus
  134. M. Böck, S. Rahrig, D. Kunz, G. Lutze, and M. U. Heim, “Platelet concentrates derived from buffy coat and apheresis: biochemical and functional differences,” Transfusion Medicine, vol. 12, no. 5, pp. 317–324, 2002. View at Publisher · View at Google Scholar · View at Scopus
  135. S. Murphy and F. H. Gardner, “Platelet storage at 22 degrees C; metabolic, morphologic, and functional studies,” Journal of Clinical Investigation, vol. 50, no. 2, pp. 370–377, 1971. View at Publisher · View at Google Scholar · View at Scopus
  136. Guidance for Industry, US Department of Health and Human Services, Washington, DC, USA, 2009.
  137. L. J. Dumont, D. F. Dumont, Z. M. Unger et al., “A randomized controlled trial comparing autologous radiolabeled in vivo platelet (PLT) recoveries and survivals of 7-day-stored PLT-rich plasma and buffy coat PLTs from the same subjects,” Transfusion, vol. 51, no. 6, pp. 1241–1248, 2011. View at Publisher · View at Google Scholar · View at Scopus
  138. L. J. Dumont, J. A. Cancelas, D. F. Dumont et al., “A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers,” Transfusion, vol. 53, no. 1, pp. 128–137, 2013. View at Publisher · View at Google Scholar · View at Scopus
  139. B. Diedrich, P. Sandgren, B. Jansson, H. Gulliksson, L. Svensson, and A. Shanwell, “In vitro and in vivo effects of potassium and magnesium on storage up to 7 days of apheresis platelet concentrates in platelet additive solution,” Vox Sanguinis, vol. 94, no. 2, pp. 96–102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  140. A. Bikker, E. Bouman, S. Sebastian et al., “Functional recovery of stored platelets after transfusion,” Transfusion, vol. 56, no. 5, pp. 1030–1037, 2016. View at Publisher · View at Google Scholar
  141. R. P. Goodrich, J. Li, H. Pieters, R. Crookes, J. Roodt, and A. D. P. Heyns, “Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects,” Vox Sanguinis, vol. 90, no. 4, pp. 279–285, 2006. View at Publisher · View at Google Scholar · View at Scopus
  142. S. J. Slichter, J. Corson, M. K. Jones et al., “Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS),” Blood, vol. 123, no. 2, pp. 271–280, 2014. View at Publisher · View at Google Scholar · View at Scopus
  143. J. C. Zimring, S. Slichter, K. Odem-Davis et al., “Metabolites in stored platelets associated with platelet recoveries and survivals,” Transfusion, vol. 56, no. 8, pp. 1974–1983, 2016. View at Publisher · View at Google Scholar
  144. C. R. Valeri, G. Ragno, and S. Khuri, “Freezing human platelets with 6 percent dimethyl sulfoxide with removal of the supernatant solution before freezing and storage at −80 degrees C without postthaw processing,” Transfusion, vol. 45, no. 12, pp. 1890–1898, 2005. View at Publisher · View at Google Scholar
  145. L. Johnson, S. Reid, S. Tan, D. Vidovic, and D. C. Marks, “PAS-G supports platelet reconstitution after cryopreservation in the absence of plasma,” Transfusion, vol. 53, no. 10, pp. 2268–2277, 2013. View at Publisher · View at Google Scholar · View at Scopus
  146. C. R. Valeri, R. Srey, J. P. Lane, and G. Ragno, “Effect of WBC reduction and storage temperature on PLTs frozen with 6 percent DMSO for as long as 3 years,” Transfusion, vol. 43, no. 8, pp. 1162–1167, 2003. View at Publisher · View at Google Scholar · View at Scopus
  147. F. Noorman, R. Strelitski, and J. Badloe, “Frozen platelets can be stored for 4 years at—80°C without affecting in vitro recovery, morphology, receptor expression, or coagulation profile,” Transfusion, vol. 54, no. S2, pp. 15A–279A, 2014. View at Google Scholar
  148. P. A. Daly, C. A. Schiffer, J. Aisner, and P. H. Wiernik, “Successful transfusion of platelets cryopreserved for more than 3 years,” Blood, vol. 54, no. 5, pp. 1023–1027, 1979. View at Google Scholar · View at Scopus
  149. C. C. M. Lelkens, J. G. Koning, B. de Kort, I. B. G. Floot, and F. Noorman, “Experiences with frozen blood products in the Netherlands military,” Transfusion and Apheresis Science, vol. 34, no. 3, pp. 289–298, 2006. View at Publisher · View at Google Scholar · View at Scopus
  150. J. Badloe and F. Noorman, “The Netherlands experience with frozen −80°C red cells, plasma and platelets in combat casualty care,” Transfusion, vol. 51, no. S3, pp. 1A–297A, 2011. View at Google Scholar
  151. R. I. Handin and C. R. Valeri, “Improved viability of previously frozen platelets,” Blood, vol. 40, no. 4, pp. 509–513, 1972. View at Google Scholar · View at Scopus
  152. C. R. Valeri, H. Feingold, and L. D. Marchionni, “A simple method for freezing human platelets using 6% dimethylsulfoxide and storage at −80°C,” Blood, vol. 43, no. 1, pp. 131–136, 1974. View at Google Scholar · View at Scopus
  153. C. R. Valeri, “Hemostatic effectiveness of liquid-preserved and previously frozen human platelets,” The New England Journal of Medicine, vol. 290, no. 7, pp. 353–358, 1974. View at Publisher · View at Google Scholar · View at Scopus
  154. S. Yılmaz, R. A. Çetinkaya, İ. Eker et al., “Freezing of apheresis platelet concentrates in 6% dimethyl sulfoxide: the first preliminary study in Turkey,” Turkish Journal of Hematology, vol. 33, no. 1, pp. 28–33, 2016. View at Publisher · View at Google Scholar · View at Scopus
  155. M. C. Reade, D. C. Marks, L. Johnson, D. O. Irving, and A. D. Holley, “Frozen platelets for rural Australia: the CLIP trial,” Anaesthesia and Intensive Care, vol. 41, no. 6, pp. 804–805, 2013. View at Google Scholar · View at Scopus
  156. J. P. Crowley, A. Rene, and C. R. Valeri, “Changes in platelet shape and structure after freeze preservation,” Blood, vol. 44, no. 4, pp. 599–603, 1974. View at Google Scholar · View at Scopus
  157. J. I. Spector, E. M. Skrabut, and C. R. Valeri, “Oxygen consumption, platelet aggregation and release reactions in platelets freeze-preserved with dimethylsulfoxide,” Transfusion, vol. 17, no. 2, pp. 99–109, 1977. View at Publisher · View at Google Scholar · View at Scopus
  158. V. S. Hornsey, L. McMillan, A. Morrison, O. Drummond, I. R. MacGregor, and C. V. Prowse, “Freezing of buffy coat-derived, leukoreduced platelet concentrates in 6 percent dimethyl sulfoxide,” Transfusion, vol. 48, no. 12, pp. 2508–2514, 2008. View at Publisher · View at Google Scholar · View at Scopus
  159. C. G. Zaroulis, J. I. Spector, C. P. Emerson, and C. R. Valeri, “Therapeutic transfusions of previously frozen washed human platelets,” Transfusion, vol. 19, no. 4, pp. 371–378, 1979. View at Publisher · View at Google Scholar · View at Scopus
  160. C. A. Schiffer, J. Aisner, and P. H. Wiernik, “Clinical experience with transfusion of cryopreserved platelets,” British Journal of Haematology, vol. 34, no. 3, pp. 377–385, 1976. View at Publisher · View at Google Scholar · View at Scopus
  161. C. A. Schiffer, J. Aisner, J. P. Dutcher, P. A. Daly, and P. H. Wiernik, “A clinical program of platelet cryopreservation,” Progress in Clinical and Biological Research, vol. 88, pp. 165–180, 1982. View at Google Scholar · View at Scopus
  162. B. Gerber, L. Alberio, S. Rochat et al., “Safety and efficacy of cryopreserved autologous platelet concentrates in HLA-alloimmunized patients with hematologic malignancies,” Transfusion, vol. 56, no. 10, pp. 2426–2437, 2016. View at Publisher · View at Google Scholar
  163. S. F. Khuri, N. Healey, H. MacGregor et al., “Comparison of the effects of transfusions of cryopreserved and liquid-preserved platelets on hemostasis and blood loss after cardiopulmonary bypass,” Journal of Thoracic and Cardiovascular Surgery, vol. 117, no. 1, pp. 172–184, 1999. View at Publisher · View at Google Scholar · View at Scopus
  164. L. Johnson, S. Raynel, J. Seghatchian, and D. C. Marks, “Platelet microparticles in cryopreserved platelets: potential mediators of haemostasis,” Transfusion and Apheresis Science, vol. 53, no. 2, pp. 146–152, 2016. View at Publisher · View at Google Scholar · View at Scopus
  165. M. R. Barnard, H. MacGregor, G. Ragno et al., “Fresh, liquid-preserved, and cryopreserved platelets: adhesive surface receptors and membrane procoagulant activity,” Transfusion, vol. 39, no. 8, pp. 880–888, 1999. View at Publisher · View at Google Scholar · View at Scopus
  166. K. Nogami, “The utility of thromboelastography in inherited and acquired bleeding disorders,” British Journal of Haematology, vol. 174, no. 4, pp. 503–514, 2016. View at Publisher · View at Google Scholar
  167. P. Cookson, A. Lawrie, L. Green et al., “Thrombin generation and coagulation factor content of thawed plasma and platelet concentrates,” Vox Sanguinis, vol. 108, no. 2, pp. 160–168, 2015. View at Publisher · View at Google Scholar · View at Scopus
  168. I. J. Bontekoe, P. F. van der Meer, and D. de Korte, “Determination of thromboelastographic responsiveness in stored single-donor platelet concentrates,” Transfusion, vol. 54, no. 6, pp. 1610–1618, 2014. View at Publisher · View at Google Scholar · View at Scopus
  169. J. Cid, G. Escolar, A. Galan et al., “In vitro evaluation of the hemostatic effectiveness of cryopreserved platelets,” Transfusion, vol. 56, no. 3, pp. 580–586, 2016. View at Publisher · View at Google Scholar
  170. R. Al Dieri, B. de Laat, and H. C. Hemker, “Thrombin generation: what have we learned?” Blood Reviews, vol. 26, no. 5, pp. 197–203, 2012. View at Publisher · View at Google Scholar · View at Scopus
  171. T. Z. Tegegn, S. H. De Paoli, M. Orecna et al., “Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets,” Journal of Extracellular Vesicles, vol. 5, Article ID 30422, 2016. View at Publisher · View at Google Scholar
  172. I. Eker, S. Yilmaz, R. A. Cetinkaya et al., “Generation of platelet microparticles after cryopreservation of apheresis platelet concentrates contribute to the hemostatic activity,” Turkish Journal of Haematology, 2016. View at Publisher · View at Google Scholar
  173. R. Cardigan, J. Sutherland, M. Garwood et al., “In vitro function of buffy coat-derived platelet concentrates stored for 9 days in CompoSol, PASII or 100% plasma in three different storage bags,” Vox Sanguinis, vol. 94, no. 2, pp. 103–112, 2008. View at Publisher · View at Google Scholar · View at Scopus
  174. L. Johnson, M. C. Reade, R. A. Hyland, S. Tan, and D. C. Marks, “In vitro comparison of cryopreserved and liquid platelets: potential clinical implications,” Transfusion, vol. 55, no. 4, pp. 838–847, 2015. View at Publisher · View at Google Scholar · View at Scopus
  175. L. M. Currie, B. Lichtiger, S. A. Livesey, W. Tansey, D. J. Yang, and J. Connor, “Enhanced circulatory parameters of human platelets cryopreserved with second-messenger effectors: an in vivo study of 16 volunteer platelet donors,” British Journal of Haematology, vol. 105, no. 3, pp. 826–831, 1999. View at Publisher · View at Google Scholar · View at Scopus
  176. J. F. W. Keuren, E. J. P. Magdeleyns, J. W. P. Govers-Riemslag, T. Lindhout, and J. Curvers, “Effects of storage-induced platelet microparticles on the initiation and propagation phase of blood coagulation,” British Journal of Haematology, vol. 134, no. 3, pp. 307–313, 2006. View at Publisher · View at Google Scholar · View at Scopus
  177. S. Raynel, M. P. Padula, D. C. Marks, and L. Johnson, “Cryopreservation alters the membrane and cytoskeletal protein profile of platelet microparticles,” Transfusion, vol. 55, no. 10, pp. 2422–2432, 2015. View at Publisher · View at Google Scholar · View at Scopus
  178. S. D. Bohling, M. B. Pagano, M. R. Stitzel, C. Ferrell, W. Yeung, and W. L. Chandler, “Comparison of clot-based vs chromogenic factor Xa procoagulant phospholipid activity assays,” American Journal of Clinical Pathology, vol. 137, no. 2, pp. 185–192, 2012. View at Publisher · View at Google Scholar · View at Scopus
  179. L. Ayers, M. Kohler, P. Harrison et al., “Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay,” Thrombosis Research, vol. 127, no. 4, pp. 370–377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  180. J.-M. Freyssinet and F. Toti, “Formation of procoagulant microparticles and properties,” Thrombosis Research, vol. 125, no. 1, pp. S46–S48, 2010. View at Publisher · View at Google Scholar · View at Scopus
  181. S. E. Headland, H. R. Jones, A. S. V. D'Sa, M. Perretti, and L. V. Norling, “Cutting-edge analysis of extracellular microparticles using ImageStreamX imaging flow cytometry,” Scientific Reports, vol. 4, article 5237, 2014. View at Publisher · View at Google Scholar · View at Scopus
  182. S. Murphy and F. H. Gardner, “Effect of storage temperature on maintenance of platelet viability—deleterious effect of refrigerated storage,” The New England Journal of Medicine, vol. 280, no. 20, pp. 1094–1098, 1969. View at Publisher · View at Google Scholar · View at Scopus
  183. A. Charlton, J. Wallis, J. Robertson, D. Watson, A. Iqbal, and H. Tinegate, “Where did platelets go in 2012? A survey of platelet transfusion practice in the North of England,” Transfusion Medicine, vol. 24, no. 4, pp. 213–218, 2014. View at Publisher · View at Google Scholar · View at Scopus
  184. B. Wood, M. P. Padula, D. C. Marks, and L. Johnson, “Refrigerated storage of platelets initiates changes in platelet surface marker expression and localization of intracellular proteins,” Transfusion, vol. 56, no. 10, pp. 2548–2559, 2016. View at Publisher · View at Google Scholar
  185. K. M. Hoffmeister, T. W. Felbinger, H. Falet et al., “The clearance mechanism of chilled blood platelets,” Cell, vol. 112, no. 1, pp. 87–97, 2003. View at Publisher · View at Google Scholar · View at Scopus
  186. D. E. Van Der Wal, V. X. Du, K. S. L. Lo, J. T. Rasmussen, S. Verhoef, and J. W. N. Akkerman, “Platelet apoptosis by cold-induced glycoprotein Ibα clustering,” Journal of Thrombosis and Haemostasis, vol. 8, no. 11, pp. 2554–2562, 2010. View at Publisher · View at Google Scholar · View at Scopus
  187. K. M. Hoffmeister and H. Falet, “Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance,” Thrombosis Research, vol. 141, supplement 2, pp. S68–S72, 2016. View at Publisher · View at Google Scholar
  188. V. Rumjantseva, P. K. Grewal, H. H. Wandall et al., “Dual roles for hepatic lectin receptors in the clearance of chilled platelets,” Nature Medicine, vol. 15, no. 11, pp. 1273–1280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  189. G. Baimukanova, B. Miyazawa, D. R. Potter et al., “The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function,” Transfusion, vol. 56, supplement 1, pp. S52–S64, 2016. View at Publisher · View at Google Scholar
  190. J. A. Bynum, M. Adam Meledeo, T. M. Getz et al., “Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability,” Transfusion, vol. 56, no. 1, pp. S76–S84, 2016. View at Publisher · View at Google Scholar
  191. P. M. Nair, H. F. Pidcoke, A. P. Cap, and A. K. Ramasubramanian, “Effect of cold storage on shear-induced platelet aggregation and clot strength,” Journal of Trauma and Acute Care Surgery, vol. 77, no. 3, supplement 2, pp. S88–S93, 2014. View at Publisher · View at Google Scholar · View at Scopus
  192. P. Sandgren, M. Hansson, H. Gulliksson, and A. Shanwell, “Storage of buffy-coat-derived platelets in additive solutions at 4°C and 22°C: flow cytometry analysis of platelet glycoprotein expression,” Vox Sanguinis, vol. 93, no. 1, pp. 27–36, 2007. View at Publisher · View at Google Scholar · View at Scopus
  193. A. P. Cap, “Platelet storage: a license to chill!,” Transfusion, vol. 56, no. 1, pp. 13–16, 2016. View at Publisher · View at Google Scholar
  194. Canadian Blood Services Annual Report 2014-2015: How we Connect, Canadian Blood Services, Ottawa, Canada, 2015.
  195. Rapport Annuel 2012-2013 d'Hema-Quebec, Hema-Quebec, Quebec, Canada, 2012.
  196. World Health Organization, WHO Global Blood Safety and Availability Fact Sheet No. 279, World Health Organization, Geneva, Switzerland, 2009.
  197. M. Raghavan and P. E. Marik, “Anemia, allogenic blood transfusion, and immunomodulation in the critically ill,” Chest, vol. 127, no. 1, pp. 295–307, 2005. View at Publisher · View at Google Scholar · View at Scopus
  198. E. Bennett-Guerrero, Y. Zhao, S. M. O'Brien et al., “Variation in use of blood transfusion in coronary artery bypass graft surgery,” The Journal of the American Medical Association, vol. 304, no. 14, pp. 1568–1575, 2010. View at Publisher · View at Google Scholar · View at Scopus
  199. N. Mohandas and J. A. Chasis, “Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids,” Seminars in Hematology, vol. 30, no. 3, pp. 171–192, 1993. View at Google Scholar · View at Scopus
  200. L. H. Derick, S.-C. Liu, A. H. Chishti, and J. Palek, “Protein immunolocalization in the spread erythrocyte membrane skeleton,” European Journal of Cell Biology, vol. 57, no. 2, pp. 317–320, 1992. View at Google Scholar · View at Scopus
  201. S. Peter Klinken, “Red blood cells,” International Journal of Biochemistry and Cell Biology, vol. 34, no. 12, pp. 1513–1518, 2002. View at Publisher · View at Google Scholar · View at Scopus
  202. D. Bratosin, J. Estaquier, J. C. Ameisen, and J. Montreuil, “Molecular and cellular mechanisms of erythrocyte programmed cell death: impact on blood transfusion,” Vox sanguinis, vol. 83, pp. 307–310, 2002. View at Publisher · View at Google Scholar · View at Scopus
  203. C. Donadee, N. J. H. Raat, T. Kanias et al., “Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion,” Circulation, vol. 124, no. 4, pp. 465–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  204. M. T. Gladwin, T. Kanias, and D. B. Kim-Shapiro, “Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease,” The Journal of Clinical Investigation, vol. 122, no. 4, pp. 1205–1208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  205. P. C. Minneci, K. J. Deans, H. Zhi et al., “Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin,” The Journal of Clinical Investigation, vol. 115, no. 12, pp. 3409–3417, 2005. View at Publisher · View at Google Scholar · View at Scopus
  206. S. Sassa, “Why heme needs to be degraded to iron, biliverdin IXα, and carbon monoxide?” Antioxidants and Redox Signaling, vol. 6, no. 5, pp. 819–824, 2004. View at Publisher · View at Google Scholar · View at Scopus
  207. R. E. Fleming and P. Ponka, “Iron overload in human disease,” New England Journal of Medicine, vol. 366, no. 4, pp. 348–359, 2012. View at Publisher · View at Google Scholar · View at Scopus
  208. E. A. Hod and S. L. Spitalnik, “Stored red blood cell transfusions: iron, inflammation, immunity, and infection,” Transfusion Clinique et Biologique, vol. 19, no. 3, pp. 84–89, 2012. View at Publisher · View at Google Scholar · View at Scopus
  209. T. Kanias and J. P. Acker, “Biopreservation of red blood cells—the struggle with hemoglobin oxidation,” The FEBS Journal, vol. 277, no. 2, pp. 343–356, 2010. View at Publisher · View at Google Scholar · View at Scopus
  210. E. A. Hod, N. Zhang, S. A. Sokol et al., “Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation,” Blood, vol. 115, no. 21, pp. 4284–4292, 2010. View at Publisher · View at Google Scholar · View at Scopus
  211. A. Tinmouth and I. Chin-Yee, “The clinical consequences of the red cell storage lesion,” Transfusion Medicine Reviews, vol. 15, no. 2, pp. 91–107, 2001. View at Publisher · View at Google Scholar · View at Scopus
  212. K. L. Scott, J. Lecak, and J. P. Acker, “Biopreservation of red blood cells: past, present, and future,” Transfusion Medicine Reviews, vol. 19, no. 2, pp. 127–142, 2005. View at Publisher · View at Google Scholar · View at Scopus
  213. D. Orlov and K. Karkouti, “The pathophysiology and consequences of red blood cell storage,” Anaesthesia, vol. 70, p. 29-e12, 2015. View at Publisher · View at Google Scholar · View at Scopus
  214. I. Chin-Yee, N. Arya, and M. S. d'almeida, “The red cell storage lesion and its implication for transfusion,” Transfusion Science, vol. 18, no. 3, pp. 447–458, 1997. View at Publisher · View at Google Scholar · View at Scopus
  215. L. C. Wolfe, “The membrane and the lesions of storage in preserved red cells,” Transfusion, vol. 25, no. 3, pp. 185–203, 1985. View at Publisher · View at Google Scholar · View at Scopus
  216. J. R. Hess, “An update on solutions for red cell storage,” Vox Sanguinis, vol. 91, no. 1, pp. 13–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  217. H. Bessos and J. Seghatchian, “Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cells,” Transfusion and Apheresis Science, vol. 32, no. 2, pp. 227–232, 2005. View at Publisher · View at Google Scholar · View at Scopus
  218. D. Bratosin, J. Mazurier, J. P. Tissier et al., “Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review,” Biochimie, vol. 80, no. 2, pp. 173–195, 1998. View at Publisher · View at Google Scholar · View at Scopus
  219. C. F. Hogman and H. T. Meryman, “Storage parameters affecting red blood cell survival and function after transfusion,” Transfusion Medicine Reviews, vol. 13, no. 4, pp. 275–296, 1999. View at Publisher · View at Google Scholar · View at Scopus
  220. I. Chin-Yee, N. Arya, and M. S. d'Almeida, “The red cell storage lesion and its implication for transfusion,” Transfusion Science, vol. 18, no. 3, pp. 447–458, 1997. View at Publisher · View at Google Scholar · View at Scopus
  221. A. Stewart, S. Urbaniak, M. Turner, and H. Bessos, “Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cells,” Transfusion, vol. 45, no. 9, pp. 1496–1503, 2005. View at Publisher · View at Google Scholar · View at Scopus
  222. P. A. Kurup, P. Arun, N. S. Gayathri, C. R. Dhanya, and A. R. Indu, “Modified formulation of CPDA for storage of whole blood, and of SAGM for storage of red blood cells, to maintain the concentration of 2,3-diphosphoglycerate,” Vox Sanguinis, vol. 85, no. 4, pp. 253–261, 2003. View at Publisher · View at Google Scholar · View at Scopus
  223. J. R. Hess and T. G. Greenwalt, “Storage of red blood cells: new approaches,” Transfusion Medicine Reviews, vol. 16, no. 4, pp. 283–295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  224. T. Hovav, S. Yedgar, N. Manny, and G. Barshtein, “Alteration of red cell aggregability and shape during blood storage,” Transfusion, vol. 39, no. 3, pp. 277–281, 1999. View at Publisher · View at Google Scholar · View at Scopus
  225. T. L. Berezina, S. B. Zaets, C. Morgan et al., “Influence of storage on red blood cell rheological properties,” Journal of Surgical Research, vol. 102, no. 1, pp. 6–12, 2002. View at Publisher · View at Google Scholar · View at Scopus
  226. R. Almizraq, J. D. R. Tchir, J. L. Holovati, and J. P. Acker, “Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality,” Transfusion, vol. 53, no. 10, pp. 2258–2267, 2013. View at Publisher · View at Google Scholar · View at Scopus
  227. R. T. Card, “Red cell membrane changes during storage,” Transfusion Medicine Reviews, vol. 2, no. 1, pp. 40–47, 1988. View at Publisher · View at Google Scholar · View at Scopus
  228. G. Deplaine, I. Safeukui, F. Jeddi et al., “The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro,” Blood, vol. 117, no. 8, pp. e88–e95, 2011. View at Publisher · View at Google Scholar · View at Scopus
  229. S. M. Frank, B. Abazyan, M. Ono et al., “Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration,” Anesthesia and Analgesia, vol. 116, no. 5, pp. 975–981, 2013. View at Publisher · View at Google Scholar · View at Scopus
  230. S. J. Brunskill, K. L. Wilkinson, C. Doree, M. Trivella, and S. Stanworth, “Transfusion of fresher versus older red blood cells for all conditions,” Cochrane Database of Systematic Reviews, no. 5, Article ID CD010801, 2015. View at Publisher · View at Google Scholar · View at Scopus
  231. L. M. G. Van De Watering, “Age of blood: does older blood yield poorer outcomes?” Current Opinion in Hematology, vol. 20, no. 6, pp. 526–532, 2013. View at Publisher · View at Google Scholar · View at Scopus
  232. W. A. Flegel, C. Natanson, and H. G. Klein, “Does prolonged storage of red blood cells cause harm?” British Journal of Haematology, vol. 165, no. 1, pp. 3–16, 2014. View at Publisher · View at Google Scholar · View at Scopus
  233. C. Lelubre and J.-L. Vincent, “Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review,” Critical Care, vol. 17, no. 2, article R66, 2013. View at Publisher · View at Google Scholar · View at Scopus
  234. T. Burnouf, M.-L. Chou, H. Goubran, F. Cognasse, O. Garraud, and J. Seghatchian, “An overview of the role of microparticles/microvesicles in blood components: are they clinically beneficial or harmful?” Transfusion and Apheresis Science, vol. 53, no. 2, pp. 137–145, 2015. View at Publisher · View at Google Scholar · View at Scopus
  235. J. Simak and M. P. Gelderman, “Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers,” Transfusion Medicine Reviews, vol. 20, no. 1, pp. 1–26, 2006. View at Publisher · View at Google Scholar · View at Scopus
  236. F. K. Keating, S. Butenas, M. K. Fung, and D. J. Schneider, “Platelet-white blood cell (WBC) interaction, WBC apoptosis, and procoagulant activity in stored red blood cells,” Transfusion, vol. 51, no. 5, pp. 1086–1095, 2011. View at Publisher · View at Google Scholar · View at Scopus
  237. R. E. Waugh, M. Narla, C. W. Jackson, T. J. Mueller, T. Suzuki, and G. L. Dale, “Rheological properties of senescent erythrocytes: loss of surface area and volume with red blood cell age,” Blood, vol. 79, no. 5, pp. 1351–1358, 1992. View at Google Scholar · View at Scopus
  238. A. Dhabangi, B. Ainomugisha, C. Cserti-Gazdewich et al., “Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the total randomized clinical trial,” Journal of the American Medical Association, vol. 314, no. 23, pp. 2514–2523, 2015. View at Publisher · View at Google Scholar · View at Scopus
  239. D. A. Fergusson, P. Hébert, D. L. Hogan et al., “Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial,” The Journal of the American Medical Association, vol. 308, no. 14, pp. 1443–1451, 2012. View at Publisher · View at Google Scholar · View at Scopus
  240. C. F. Högman and H. T. Meryman, “Red blood cells intended for transfusion: quality criteria revisited,” Transfusion, vol. 46, no. 1, pp. 137–142, 2006. View at Publisher · View at Google Scholar · View at Scopus
  241. A. Chabanel, M. Masse, and S. Begue, “National French observatory of the quality of blood components for transfusion,” Transfusion Clinique et Biologique, vol. 15, no. 3, pp. 85–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  242. K. Radwanski, F. Cognasse, O. Garraud, J.-M. Payrat, and K. Min, “Comparison of apheresis and 24h RT held red cell concentrates by measurement of storage lesion parameters and neutrophil activating factors during 42-day storage,” Transfusion and Apheresis Science, vol. 48, no. 2, p. 169, 2013. View at Publisher · View at Google Scholar · View at Scopus
  243. C. F. Hogman, L. Eriksson, K. Hedlund, and J. Wallvik, “The bottom and top system: a new technique for blood component preparation and storage,” Vox Sanguinis, vol. 55, no. 4, pp. 211–217, 1988. View at Publisher · View at Google Scholar · View at Scopus
  244. F. Bennardello, C. Fidone, V. Spadola et al., “The prevention of adverse reactions to transfusions in patients with haemoglobinopathies: a proposed algorithm,” Blood Transfusion, vol. 11, no. 3, pp. 377–384, 2013. View at Publisher · View at Google Scholar · View at Scopus
  245. G. M. D'Amici, C. Mirasole, A. D'Alessandro, T. Yoshida, L. J. Dumont, and L. Zolla, “Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome,” Blood Transfusion, vol. 10, supplement 2, pp. s46–s54, 2012. View at Google Scholar · View at Scopus
  246. C. F. Högman, “Liquid-stored red blood cells for transfusion: a status report,” Vox Sanguinis, vol. 76, no. 2, pp. 67–77, 1999. View at Publisher · View at Google Scholar · View at Scopus
  247. L. M. G. van de Watering, “Effects of red blood cell storage in heavily transfused patients,” Current Opinion in Anaesthesiology, vol. 26, no. 2, pp. 204–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  248. B. Bicalho, A. S. Pereira, and J. P. Acker, “Buffy coat (top/bottom)- and whole-blood filtration (top/top)-produced red cell concentrates differ in size of extracellular vesicles,” Vox Sanguinis, vol. 109, no. 3, pp. 214–220, 2015. View at Publisher · View at Google Scholar · View at Scopus
  249. A. L. Hansen, J. D. R. Kurach, T. R. Turner et al., “The effect of processing method on the in vitro characteristics of red blood cell products,” Vox Sanguinis, vol. 108, no. 4, pp. 350–358, 2015. View at Publisher · View at Google Scholar · View at Scopus
  250. J. P. Acker, A. L. Hansen, J. D. R. Kurach, T. R. Turner, I. Croteau, and C. Jenkins, “A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing,” Transfusion, vol. 54, no. 10, pp. 2534–2543, 2014. View at Publisher · View at Google Scholar · View at Scopus
  251. S. Bakkour, J. P. Acker, D. M. Chafets et al., “Manufacturing method affects mitochondrial DNA release and extracellular vesicle composition in stored red blood cells,” Vox Sanguinis, vol. 111, no. 1, pp. 22–32, 2016. View at Publisher · View at Google Scholar
  252. S. M. Picker, S. M. Radojska, and B. S. Gathof, “In vitro quality of red blood cells (RBCs) collected by multicomponent apheresis compared to manually collected RBCs during 49 days of storage,” Transfusion, vol. 47, no. 4, pp. 687–696, 2007. View at Publisher · View at Google Scholar · View at Scopus
  253. S. Holme, M. Dean Elfath, and P. Whitley, “Evaluation of in vivo and in vitro quality of apheresis-collected RBC stored for 42 days,” Vox Sanguinis, vol. 75, no. 3, pp. 212–217, 1998. View at Publisher · View at Google Scholar · View at Scopus
  254. N. M. Heddle, D. M. Arnold, J. P. Acker et al., “Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study,” The Lancet Haematology, vol. 3, no. 5, pp. e246–e254, 2016. View at Publisher · View at Google Scholar
  255. R. A. Middelburg, D. Van Stein, B. Zupanska et al., “Female donors and transfusion-related acute lung injury: a case-referent study from the International TRALI Unisex Research Group,” Transfusion, vol. 50, no. 11, pp. 2447–2454, 2010. View at Publisher · View at Google Scholar
  256. A. Jordan, D. Chen, Q. -. Yi, T. Kanias, M. T. Gladwin, and J. P. Acker, “Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data,” Vox Sanguinis, vol. 111, no. 1, pp. 8–15, 2016. View at Publisher · View at Google Scholar
  257. J. S. Raval, J. H. Waters, A. Seltsam et al., “Menopausal status affects the susceptibility of stored RBCs to mechanical stress,” Vox Sanguinis, vol. 100, no. 4, pp. 418–421, 2011. View at Publisher · View at Google Scholar · View at Scopus
  258. V. L. Tzounakas, A. G. Kriebardis, I. S. Papassideri, and M. H. Antonelou, “Donor-variation effect on red blood cell storage lesion: a close relationship emerges,” PROTEOMICS—Clinical Applications, vol. 10, no. 8, pp. 791–804, 2016. View at Publisher · View at Google Scholar
  259. M. Detraglia, F. B. Cook, D. M. Stasiw, and L. C. Cerny, “Erythrocyte fragility in aging,” Biomembranes, vol. 345, no. 2, pp. 213–219, 1974. View at Publisher · View at Google Scholar · View at Scopus
  260. V. L. Tzounakas, H. T. Georgatzakou, A. G. Kriebardis et al., “Donor variation effect on red blood cell storage lesion: a multivariable, yet consistent, story,” Transfusion, vol. 56, no. 6, pp. 1274–1286, 2016. View at Publisher · View at Google Scholar
  261. T. Kanias, D. Sinchar, D. Osei-Hwedieh et al., “Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease,” Transfusion, vol. 56, no. 10, pp. 2571–2583, 2016. View at Publisher · View at Google Scholar
  262. R. Sparrow and K. A. Payne, “Donor factors, rather than physical variables of red blood cell components determine the level of hemolysis at 42 days of storage,” Transfusion, vol. 55, no. S3, pp. 55A–56A, 2015. View at Publisher · View at Google Scholar
  263. T. Kanias, M. C. Lanteri, S. M. Keating et al., “Genetic, ethnic and gender determinants of red blood storage and stress hemolysis,” Transfusion, vol. 55, no. S3, pp. 38A–39A, 2015. View at Google Scholar
  264. T. J. Van't Erve, B. A. Wagner, S. M. Martin et al., “The heritability of hemolysis in stored human red blood cells,” Transfusion, vol. 55, no. 6, pp. 1178–1185, 2015. View at Publisher · View at Google Scholar · View at Scopus
  265. J. S. Raval, J. H. Waters, A. Seltsam et al., “The use of the mechanical fragility test in evaluating sublethal RBC injury during storage,” Vox Sanguinis, vol. 99, no. 4, pp. 325–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  266. M. Ciavatti, A. Jouvenceaux, B. Chataing et al., “Changes in the erythrocyte membrane during blood preservation. Influence of progesterone,” Revues Francais Transfusion Immunohematologie, vol. 19, no. 4, pp. 539–554, 1976. View at Publisher · View at Google Scholar
  267. J. M. Rifkind, K. Araki, J. G. Mohanty, and T. Suda, “Age dependent changes in erythrocyte membrane function,” Progress in clinical and biological research, vol. 195, pp. 159–172, 1985. View at Google Scholar · View at Scopus
  268. N. J. Rencricca, J. Solomon, W. J. Fimian Jr., D. Howard, V. Rizzoli, and F. Stohlman Jr., “The effect of testosterone on erythropoiesis,” Scandinavian Journal of Haematology, vol. 6, no. 6, pp. 431–436, 1969. View at Google Scholar · View at Scopus
  269. A. Jordan, Q.-L. Yi, and J. P. Acker, “Age matters: how donor characteristics influence red cell product quality,” Transfusion, vol. 55, no. S3, pp. 77A–78A, 2015. View at Google Scholar
  270. R. A. Middelburg, E. Briët, and J. G. Van der Bom, “Mortality after transfusions, relation to donor sex,” Vox Sanguinis, vol. 101, no. 3, pp. 221–229, 2011. View at Publisher · View at Google Scholar · View at Scopus
  271. M. Chassé, A. Tinmouth, S. W. English et al., “Association of blood donor age and sex with recipient survival after red blood cell transfusion,” JAMA Internal Medicine, vol. 176, no. 9, pp. 1307–1314, 2016. View at Publisher · View at Google Scholar
  272. H. Bjursten, A. Dardashti, J. Björk, P. Wierup, L. Algotsson, and P. Ederoth, “Transfusion of sex-mismatched and non-leukocyte-depleted red blood cells in cardiac surgery increases mortality,” Journal of Thoracic and Cardiovascular Surgery, 2015. View at Publisher · View at Google Scholar · View at Scopus
  273. R. L. Barty, R. J. Cook, Y. Liu et al., “Exploratory analysis of the association between donor sex and in-hospital mortality in transfusion recipients,” Transfusion, vol. 55, no. S3, pp. 23A–24A, 2015. View at Publisher · View at Google Scholar
  274. M. Desmarets, L. Bardiaux, E. Benzenine et al., “Effect of storage time and donor sex of transfused red blood cells on 1-year survival in patients undergoing cardiac surgery: an observational study,” Transfusion, vol. 56, no. 5, pp. 1213–1222, 2016. View at Publisher · View at Google Scholar
  275. S. K. Vasan, F. Chiesa, K. Rostgaard et al., “Lack of association between blood donor age and survival of transfused patients,” Blood, vol. 127, no. 5, pp. 658–661, 2016. View at Publisher · View at Google Scholar · View at Scopus
  276. J. Treleaven, A. Gennery, J. Marsh et al., “Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force,” British Journal of Haematology, vol. 152, no. 1, pp. 35–51, 2011. View at Publisher · View at Google Scholar · View at Scopus
  277. G. Moroff and N. L. C. Luban, “The irradiation of blood and blood components to prevent graft-versus-host disease: technical issues and guidelines,” Transfusion Medicine Reviews, vol. 11, no. 1, pp. 15–26, 1997. View at Publisher · View at Google Scholar · View at Scopus
  278. H. M. Zbikowska and A. Antosik, “Irradiation dose-dependent oxidative changes in red blood cells for transfusion,” International Journal of Radiation Biology, vol. 88, no. 9, pp. 654–660, 2012. View at Publisher · View at Google Scholar · View at Scopus
  279. R. Katharia, R. Chaudhary, and P. Agarwal, “Prestorage gamma irradiation induces oxidative injury to red cells,” Transfusion and Apheresis Science, vol. 48, no. 1, pp. 39–43, 2013. View at Publisher · View at Google Scholar · View at Scopus
  280. G. Moroff and N. L. C. Luban, “The influence of gamma irradiation on red cell and platelet properties,” Transfusion Science, vol. 15, no. 2, pp. 141–148, 1994. View at Publisher · View at Google Scholar · View at Scopus
  281. K. Raghavendran, J. Nemzek, L. M. Napolitano, and P. R. Knight, “Aspiration-induced lung injury,” Critical Care Medicine, vol. 39, no. 4, pp. 818–826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  282. H. Relevy, A. Koshkaryev, N. Manny, S. Yedgar, and G. Barshtein, “Blood banking-induced alteration of red blood cell flow properties,” Transfusion, vol. 48, no. 1, pp. 136–146, 2008. View at Publisher · View at Google Scholar · View at Scopus
  283. R. M. Patel, J. D. Roback, K. Uppal, T. Yu, D. P. Jones, and C. D. Josephson, “Metabolomics profile comparisons of irradiated and nonirradiated stored donor red blood cells,” Transfusion, vol. 55, no. 3, pp. 544–552, 2015. View at Publisher · View at Google Scholar · View at Scopus
  284. D. Xu, M. Peng, Z. Zhang, G. Dong, Y. Zhang, and H. Yu, “Study of damage to red blood cells exposed to different doses of γ-ray irradiation,” Blood Transfusion, vol. 10, no. 3, pp. 321–330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  285. H. El Kenz, F. Corazza, P. Van Der Linden, S. Chabab, and C. Vandenvelde, “Potassium content of irradiated packed red blood cells in different storage media: is there a need for additive solution-dependent recommendations for infant transfusion?” Transfusion and Apheresis Science, vol. 49, no. 2, pp. 249–253, 2013. View at Publisher · View at Google Scholar · View at Scopus
  286. S. K. Harm, J. S. Raval, J. Cramer, J. H. Waters, and M. H. Yazer, “Haemolysis and sublethal injury of RBCs after routine blood bank manipulations,” Transfusion Medicine, vol. 22, no. 3, pp. 181–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  287. A. C. Lee, L. L. Reduque, N. L. C. Luban, P. M. Ness, B. Anton, and E. S. Heitmiller, “Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion,” Transfusion, vol. 54, no. 1, pp. 244–254, 2014. View at Publisher · View at Google Scholar · View at Scopus
  288. A. Vraets, Y. Lin, and J. L. Callum, “Transfusion-associated hyperkalemia,” Transfusion Medicine Reviews, vol. 25, no. 3, pp. 184–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  289. K. Serrano, D. Chen, A. L. Hansen et al., “The effect of timing of gamma-irradiation on hemolysis and potassium release in leukoreduced red cell concentrates stored in SAGM,” Vox Sanguinis, vol. 106, no. 4, pp. 379–381, 2014. View at Publisher · View at Google Scholar · View at Scopus
  290. D. de Korte, H. Croxon, J. Petrick et al., “Timing of gamma irradiation and sex of blood donor influences in vitro characteristics of red cell concentrates,” Transfusion, vol. 55, no. S3, p. 38A, 2015. View at Google Scholar
  291. P. Mazur, “Basic problems in cryobiology,” in Advances in Cryogenic Engineering, K. D. Timmerhaus, Ed., pp. 28–37, Plenum Press, New York, NY, USA, 1964. View at Google Scholar
  292. J. Lecak, K. Scott, C. Young, J. Hannon, and J. P. Acker, “Evaluation of red blood cells stored at −80°C in excess of 10 years,” Transfusion, vol. 44, no. 9, pp. 1306–1313, 2004. View at Publisher · View at Google Scholar · View at Scopus
  293. C. R. Valeri, G. Ragno, L. E. Pivacek et al., “An experiment with glycerol-frozen red blood cells stored at -80°C for up to 37 years,” Vox Sanguinis, vol. 79, no. 3, pp. 168–174, 2000. View at Publisher · View at Google Scholar · View at Scopus
  294. M. A. Schreiber, B. H. McCully, J. B. Holcomb et al., “Transfusion of cryopreserved packed red blood cells is safe and effective after trauma: a prospective randomized trial,” Annals of Surgery, vol. 262, no. 3, pp. 426–432, 2015. View at Publisher · View at Google Scholar · View at Scopus
  295. D. A. Hampton, C. Wiles, L. J. Fabricant et al., “Cryopreserved red blood cells are superior to standard liquid red blood cells,” Journal of Trauma and Acute Care Surgery, vol. 77, no. 1, pp. 20–27, 2014. View at Publisher · View at Google Scholar · View at Scopus
  296. J. E. Lovelock, “The mechanism of the protective action of glycerol against haemolysis by freezing and thawing,” Biochimica et Biophysica Acta, vol. 11, pp. 28–36, 1953. View at Publisher · View at Google Scholar
  297. A. U. Smith, “Prevention of hæmolysis during freezing and thawing of red blood-cells,” The Lancet, vol. 256, no. 6644, pp. 910–911, 1950. View at Publisher · View at Google Scholar · View at Scopus
  298. A. W. Rowe, E. Eyster, and A. Kellner, “Liquid nitrogen preservation of red blood cells for transfusion: a low glycerol—rapid freeze procedure,” Cryobiology, vol. 5, no. 2, pp. 119–128, 1968. View at Publisher · View at Google Scholar · View at Scopus
  299. H. W. Krijnen, J. J. De Wit, A. C. J. Kuivenhoven, J. A. Loos, and H. K. Prins, “Glycerol treated human red cells frozen with liquid nitrogen,” Vox Sanguinis, vol. 9, pp. 559–572, 1964. View at Publisher · View at Google Scholar · View at Scopus
  300. J. H. Pert, P. K. Schork, and R. Moore, “Low-temperature preservation of human erythrocytes: biochemical and clinical aspects,” Bibliotheca haematologica, vol. 19, pp. 47–53, 1964. View at Google Scholar · View at Scopus
  301. H. T. Meryman and M. Hornblower, “A method for freezing and washing red blood cells using a high glycerol concentration,” Transfusion, vol. 12, no. 3, pp. 145–156, 1972. View at Google Scholar · View at Scopus
  302. J. L. Tullis, M. M. Ketchel, H. M. Pyle et al., “Studies on the in vivo survival of glycerolized and frozen human red blood cells,” The Journal of the American Medical Association, vol. 168, no. 4, pp. 399–404, 1958. View at Publisher · View at Google Scholar · View at Scopus
  303. Standards for Blood Banks and Transfusion Services, vol. 127, American Association of Blood Banks, Bethesda, Md, USA, 22nd edition, 2003.
  304. M. F. O'Leary, P. Szklarski, T. M. Klein, and P. P. Young, “Hemolysis of red blood cells after cell washing with different automated technologies: clinical implications in a neonatal cardiac surgery population,” Transfusion, vol. 51, no. 5, pp. 955–960, 2011. View at Publisher · View at Google Scholar · View at Scopus
  305. A. A. R. Tobian, W. J. Savage, D. J. Tisch, S. Thoman, K. E. King, and P. M. Ness, “Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction,” Transfusion, vol. 51, no. 8, pp. 1676–1683, 2011. View at Publisher · View at Google Scholar · View at Scopus
  306. C. C. Silliman, E. E. Moore, J. L. Johnson, R. J. Gonzalez, and W. L. Biffl, “Transfusion of the injured patient: proceed with caution,” Shock, vol. 21, no. 4, pp. 291–299, 2004. View at Publisher · View at Google Scholar · View at Scopus
  307. J. M. Cholette, K. F. Henrichs, G. M. Alfieris et al., “Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial,” Pediatric Critical Care Medicine, vol. 13, no. 3, pp. 290–299, 2012. View at Publisher · View at Google Scholar · View at Scopus
  308. T. Smith, W. Riley, and D. Fitzgerald, “In vitro comparison of two different methods of cell washing,” Perfusion, vol. 28, no. 1, pp. 34–37, 2013. View at Publisher · View at Google Scholar · View at Scopus
  309. M. Gruber, A. Breu, M. Frauendorf, T. Seyfried, and E. Hansen, “Washing of banked blood by three different blood salvage devices,” Transfusion, vol. 53, no. 5, pp. 1001–1009, 2013. View at Publisher · View at Google Scholar · View at Scopus
  310. A. Hansen, Q.-L. Yi, and J. P. Acker, “Quality of red blood cells washed using the ACP 215 cell processor: assessment of optimal pre- and postwash storage times and conditions,” Transfusion, vol. 53, no. 8, pp. 1772–1779, 2013. View at Publisher · View at Google Scholar · View at Scopus
  311. Standards for Blood Banks and Transfusion Services, AABB, Bethesda, Md, USA, 2012.
  312. CAN/CSA-Z902-10 Blood and Blood Components, Canadian Standards Association, Mississauga, Canada, 2010.
  313. A. L. Hansen, T. R. Turner, J. D. R. Kurach, and J. P. Acker, “Quality of red blood cells washed using a second wash sequence on an automated cell processor,” Transfusion, vol. 55, no. 10, pp. 2415–2421, 2015. View at Publisher · View at Google Scholar · View at Scopus
  314. C. B. Tóth, J. Kramer, J. Pinter, M. Thék, and J. E. Szabó, “IgA content of washed red blood cell concentrates,” Vox Sanguinis, vol. 74, no. 1, pp. 13–14, 1998. View at Publisher · View at Google Scholar · View at Scopus
  315. L. R. Bryant, L. Holland, and S. Corkern, “Optimal leukocyte removal from refrigerated blood with the IBM 2991 blood cell processor,” Transfusion, vol. 18, no. 4, pp. 469–471, 1978. View at Publisher · View at Google Scholar · View at Scopus
  316. B. Wenz, “Clinical and laboratory precautions that reduce the adverse reactions, alloimmunization, infectivity, and possibly immunomodulation associated with homologous transfusions,” Transfusion Medicine Reviews, vol. 4, no. 4, supplement 1, pp. 3–7, 1990. View at Publisher · View at Google Scholar · View at Scopus
  317. K. L. Lannan, J. Sahler, S. L. Spinelli, R. P. Phipps, and N. Blumberg, “Transfusion immunomodulation—the case for leukoreduced and (perhaps) washed transfusions,” Blood Cells, Molecules, and Diseases, vol. 50, no. 1, pp. 61–68, 2013. View at Publisher · View at Google Scholar · View at Scopus
  318. M. A. Refaai and N. Blumberg, “Transfusion immunomodulation from a clinical perspective: an update,” Expert Review of Hematology, vol. 6, no. 6, pp. 653–663, 2013. View at Publisher · View at Google Scholar · View at Scopus
  319. I. Corteś-Puch, D. Wang, J. Sun et al., “Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia,” Blood, vol. 123, no. 9, pp. 1403–1411, 2014. View at Publisher · View at Google Scholar · View at Scopus
  320. R. M. Belizaire, A. T. Makley, E. M. Campion et al., “Resuscitation with washed aged packed red blood cell units decreases the proinflammatory response in mice after hemorrhage,” Journal of Trauma and Acute Care Surgery, vol. 73, no. 2, supplement 1, pp. S128–S133, 2012. View at Publisher · View at Google Scholar · View at Scopus
  321. V. Weisbach, W. Riego, E. Strasser et al., “The in vitro quality of washed, prestorage leucocyte-depleted red blood cell concentrates,” Vox Sanguinis, vol. 87, no. 1, pp. 19–26, 2004. View at Publisher · View at Google Scholar · View at Scopus
  322. R. de Vroege, W. R. Wildevuur, J. A. G. Muradin, D. Graves, and W. van Oeveren, “Washing of stored red blood cells by an autotransfusion device before transfusion,” Vox Sanguinis, vol. 92, no. 2, pp. 130–135, 2007. View at Publisher · View at Google Scholar · View at Scopus
  323. B. Westphal-Varghese, M. Erren, M. Westphal et al., “Processing of stored packed red blood cells using autotransfusion devices decreases potassium and microaggregates: a prospective, randomized, single-blinded in vitro study,” Transfusion Medicine, vol. 17, no. 2, pp. 89–95, 2007. View at Publisher · View at Google Scholar · View at Scopus
  324. R. Mancini, L. Marinelli, N. Mirante et al., “Evaluation of haemoglobin, haematocrit, haemolysis, residual protein content and leucocytes in 345 red blood cell concentrates used for the treatment of patients with β-thalassaemia,” Blood Transfusion, vol. 10, no. 1, pp. 39–44, 2012. View at Publisher · View at Google Scholar · View at Scopus
  325. T. J. Contreras and C. R. Valeri, “A comparison of methods to wash liquid-stored red blood cells and red blood cells frozen with high or low concentrations of glycerol,” Transfusion, vol. 16, no. 6, pp. 539–565, 1976. View at Publisher · View at Google Scholar · View at Scopus
  326. A. L. Hansen, T. R. Turner, Q.-L. Yi, and J. P. Acker, “Quality of red blood cells washed using an automated cell processor with and without irradiation,” Transfusion, vol. 54, no. 6, pp. 1585–1594, 2014. View at Publisher · View at Google Scholar · View at Scopus
  327. S. O. Sowemimo-Coker, “Red blood cell hemolysis during processing,” Transfusion Medicine Reviews, vol. 16, no. 1, pp. 46–60, 2002. View at Publisher · View at Google Scholar · View at Scopus
  328. D. de Korte and A. J. Verhoeven, “Quality determinants of erythrocyte destined for transfusion,” Cellular and molecular biology (Noisy-le-Grand, France), vol. 50, no. 2, pp. 187–195, 2004. View at Google Scholar · View at Scopus
  329. J. R. Hess, “Measures of stored red blood cell quality,” Vox Sanguinis, vol. 107, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar · View at Scopus
  330. L. J. Dumont and J. P. Aubuchon, “Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials,” Transfusion, vol. 48, no. 6, pp. 1053–1060, 2008. View at Publisher · View at Google Scholar · View at Scopus
  331. W. A. Heaton, “Evaluation of posttransfusion recovery and survival of transfused red cells,” Transfusion medicine reviews, vol. 6, no. 3, pp. 153–169, 1992. View at Publisher · View at Google Scholar · View at Scopus
  332. K. J. Wardrop, R. L. Tucker, and E. P. Anderson, “Use of an in vitro biotinylation technique for determination of posttransfusion viability of stored canine packed red blood cells,” American Journal of Veterinary Research, vol. 59, no. 4, pp. 397–400, 1998. View at Google Scholar · View at Scopus
  333. D. M. Mock, J. A. Widness, P. Veng-Pedersen et al., “Measurement of posttransfusion red cell survival with the biotin label,” Transfusion Medicine Reviews, vol. 28, no. 3, pp. 114–125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  334. J. Creteur, A. P. Neves, and J.-L. Vincent, “Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation,” Critical Care, vol. 13, supplement 5, article S11, 2009. View at Publisher · View at Google Scholar · View at Scopus
  335. M. G. Risbano, T. Kanias, D. Triulzi et al., “Effects of aged stored autologous red blood cells on human endothelial function,” American Journal of Respiratory and Critical Care Medicine, vol. 192, no. 10, pp. 1223–1233, 2015. View at Publisher · View at Google Scholar · View at Scopus
  336. S. O. Sowemimo-Coker, J. Acker, M. Narla et al., “Development of a statistical model for predicting in vivo viability of red blood cells: importance of red cell membrane damages,” Transfusion, vol. 55, no. S3, pp. 56A–57A, 2015. View at Google Scholar