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Journal of Cancer Epidemiology
Volume 2009, Article ID 242151, 12 pages
Research Article

Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

1Cancer Biology Program, School of Medicine, Wayne State University, 4100 John R, Detroit, MI 48201, USA
2Population Studies and Prevention Program, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
3Department of Internal Medicine, School of Medicine, Wayne State University, 4100 John R, Detroit, MI 48201, USA
4Biostatistics Core, Karmanos Cancer Institute, 716 Harper Professional Building, 4160 John R, Detroit, MI 48201, USA
5Applied Genomics Technology Center and Department of Obstetrics & Gynecology, Wayne State University School of Medicine & Genomics Core, Karmanos Cancer Institute, Mott Center, 275 E Hancock, Detroit, MI 48201, USA

Received 1 September 2009; Accepted 14 December 2009

Academic Editor: Carmen J. Marsit

Copyright © 2009 Alison L. Van Dyke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores. Smoking-SNP interactions were explored, and haplotypes in TERT and GHR associated with NSCLC risk were identified. The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration.