Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

Table 2

Associations between chromosome 5p SNPs and risk of NSCLC by race under a dominant model.

			Caucasians				African Americans
Gene	SNP Identifier		Minor Allele Freq (%) Controls	Hap Map CEU Allele Freq	OR^1; (95% CI)	Gene P-value^2	Minor Allele Freq (%) Controls^3	Hap Map ASW Allele Freq	OR^1; (95% CI)	Gene P-value^2	Comparison of Variant Allele Freq. P-value^2
AHRR	rs34847072	2912 bp 3^′ of STP G/C	0.37	N/A	0.93 (0.64–1.35)		0.10	N/A	1.03 (0.43–2.47)		<.0001
AHRR	rs10078	3152 bp 3^′ of STP T/G	0.22	0.18	0.84 (0.58–1.22)	.22	0.26	0.23	0.65 (0.32–1.31)	.08	.34
TERT	rs2853690	Ex16 + 203 G/A	0.18	0.16	0.92 (0.62–1.36)		0.34	0.29	0.81 (0.40–1.60)		<.0001
TERT	rs2075786	IVS10 + 269 G/A	0.33	0.40	1.17 (0.81–1.70)		0.48	N/A	3.04 (1.26–7.30)		<.0001
TERT	rs2853677	IVS2-4455 A/G	0.44	0.42	1.76 (1.16–2.67)		0.23	0.36	2.18 (1.08–4.38)		<.0001
TERT	rs2735940^2	−1381 A/G	0.49	N/A	0.99 (0.66–1.49)		0.55	N/A	0.38 (0.17–0.85)		.15
TERT	rs1801075	−22844 T/C	0.16	0.18	1.00 (0.68–1.49)	.06	0.16	0.12	1.12 (0.54–2.29)	.02	1.00
SLC6A3	rs6347^2	S^405S	0.25	0.25	1.10 (0.76–1.58)		0.55	0.48	0.68 (0.30–1.56)		<.0001
SLC6A3	rs460700	IVS4 + 2610 T/C	0.23	0.30	0.79 (0.54–1.15)		0.32	N/A	0.79 (0.40–1.57)		.01
SLC6A3	rs2652511^2	−3076 G/A	0.42	N/A	1.34 (0.90–2.00)	.17	0.65	N/A	0.92 (0.34–2.48)	.25	<.0001
MTRR	rs10380	H^622Y	0.10	0.16	0.94 (0.59–1.49)		0.33	0.28	1.06 (0.53–2.11)		<.0001
MTRR	rs1802059	A^664A	0.39	0.31	0.88 (0.61–1.28)		0.26	0.32	1.02 (0.52–2.02)		.002
MTRR	rs9332	Ex15-526 G/A	0.11	0.19	1.01 (0.65–1.56)		0.37	0.33	1.01 (0.50–2.03)		<.0001
MTRR	rs8659^2	Ex15-405 A/T	0.36	0.46	1.04 (0.72–1.51)	.81	0.51	N/A	0.90 (0.40–2.04)	.89	.0001
AMACR	rs2278008	K^277E	0.26	0.20	1.14 (0.79–1.64)		0.23	0.17	0.99 (0.48–2.05)		.36
AMACR	rs840409	IVS4 + 3803 G/C	0.12	0.13	1.03 (0.66–1.59)		0.10	.04	0.59 (0.23–1.52)		.65
AMACR	rs34677	Q^239H	0.15	0.15	0.98 (0.66–1.48)		0.11	.05	0.88 (0.36–2.06)		.15
AMACR	rs2287939	S^201L	0.28	0.27	1.18 (0.82–1.70)		0.16	0.20	0.67 (0.31–1.44)		.0009
AMACR	rs10941112^2	D^175G	0.48	0.44	1.20 (0.80–1.82)		0.89	0.88	1.54 (0.18–13.08)		<.0001
AMACR	rs34689^2	IVS1 + 169 A/C	0.18	0.17	1.03 (0.70–1.52)	.63	0.50	0.47	0.58 (0.27–1.25)	.02	<.0001
GHR	rs2972395	−165670 C/T	0.21	0.10	0.88 (0.60–1.28)		0.22	N/A	1.00 (0.48–2.08)		.83
GHR	rs2940930	−160465 G/A	0.36	0.36	0.76 (0.52–1.11)		0.14	0.16	1.72 (0.84–3.53)		<.0001
GHR	rs7732059	−142504 G/C	0.22	N/A	1.29 (0.90–1.87)		0.32	N/A	1.30 (0.65–2.59)		.01
GHR	rs1858136	IVS1 + 12052 G/C	0.21	0.10	0.86 (0.59–1.26)		0.26	N/A	0.69 (0.34–1.40)		.15
GHR	rs2972418^2	IVS1 + 59636 T/C	0.48	0.50	1.12 (0.74–1.72)		0.67	0.65	0.66 (0.23–1.91)		<.0001
GHR	rs2972419	IVS1 + 59820 G/A	0.21	0.15	0.93 (0.63–1.36)		0.22	0.29	0.98 (0.47–2.02)		.87
GHR	rs2940944^2	IVS1 + 65085 A/C	0.46	0.49	1.25 (0.83–1.89)		0.58	0.56	1.14 (0.48–2.72)		.004
GHR	rs2972392^2	IVS1 − 70131 A/C	0.41	N/A	1.30 (0.87–1.93)		0.57	N/A	1.07 (0.46–2.52)		<.0001
GHR	rs33939197	IVS1− 69908 T/C	0.19	N/A	1.29 (0.88–1.87)		0.16	N/A	0.86 (0.39–1.90)		.34
GHR	rs2940913^2	IVS1− 66349 G/T	0.46	0.47	1.25 (0.83–1.89)		0.67	N/A	0.60 (0.20–1.82)		<.0001
GHR	rs7735889	IVS1− 3767 A/G	0.25	0.34	1.10 (0.76–1.58)		0.61	0.47	0.54 (0.23–1.30)		<.0001
GHR	rs7712701	IVS2 + 4144 C/A	0.23	N/A	1.20 (0.83–1.74)		0.61	N/A	0.81 (0.33–2.00)		<.0001
GHR	rs28943882	IVS2 + 29065 C/T	0.17	0.21	1.16 (0.80–1.70)		0.42	0.27	1.06 (0.52–2.15		<.0001
GHR	rs6873545	IVS3 + 2059 T/C	0.26	0.28	1.53 (1.05–2.21)		0.45	0.58	1.12 (0.53–2.38)		<.0001
GHR	rs4451056	IVS3 + 26148 G/C	0.15	0.18	1.49 (1.01–2.20)		0.18	N/A	0.69 (0.33–1.45)		.31
GHR	rs6878512	IVS3− 21121 C/T	0.15	0.16	1.54 (1.04–2.27)		0.23	N/A	0.68 (0.34–1.38)		.005
GHR	rs6897530^2	IVS3− 21055 T/C	0.26	N/A	1.54 (1.06–2.23)		0.54	N/A	0.97 (0.42–2.28)		<.0001
GHR	rs6179^2	G^186G	0.26	0.29	1.46 (1.01–2.11)		0.60	0.64	0.91 (0.33–2.48)		<.0001
GHR	rs2972780^2	IVS8 + 1229 C/T	0.25	0.26	1.50 (1.04–2.17)		0.58	N/A	0.78 (0.30–2.00)		<.0001
GHR	rs6180	Ex10 + 685 A/C	0.47	0.45	0.73 (0.48–1.10)	.06	0.35	0.29	1.00 (0.49–2.03)	.03	.003
SEPP1	rs6413428	Ex5 + 710 A/G	0.23	0.26	1.56 (1.08–2.26)		0.34	0.38	0.70 (0.34–1.42)		.002
SEPP1	rs7579	Ex5 + 626 C/T	0.28	0.30	1.08 (0.75–1.55)	.06	0.16	0.17	0.78 (0.37–1.66)	.25	.0009

¹Adjusted for age at diagnosis/interview, smoking pack-year history, years of education, family history of lung cancer, history of COPD, adult aspirin use (never/ever), and BMI. ²Adjusted for multiple comparisons via the Benjamini and Hochberg False Discovery Rate (FDR) method. ³The minor allele differed for Caucasians and African Americans for the SNPs for which minor allele frequencies are bolded.