Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women
Table 4
Chromosome p SNPs and NSCLC Risk by Smoking History (Never/Ever) among Caucasians1.
Never smokers
Ever smokers
SNP
OR2 (95% CI)
OR3 (95% CI)
rs2853677-TERT
AA
5
61
1.00
76
60
1.00
AG/GG
29
132
2.43 (0.88–6.72)
247
125
1.62 (1.01–2.60)
rs6873545-GHR
TT
17
100
1.00
159
104
1.00
TC/CC
19
92
0.99 (0.47–2.09)
168
82
1.79 (1.16–2.78)
rs6897530-GHR
TT
17
103
1.00
158
105
1.00
TC/CC
19
90
1.02 (0.48–2.16)
169
81
1.80 (1.16–2.78)
rs6179-GHR
GG
18
106
1.00
154
101
1.00
GA/AA
18
88
0.93 (0.44–1.96)
174
85
1.70 (1.10–2.62)
rs2972780-GHR
CC
17
108
1.00
156
104
1.00
CT/TT
19
86
1.09 (0.52–2.31)
172
82
1.67 (1.08–2.58)
rs6413428-SEPP1
AA
17
116
1.00
165
108
1.00
AG/GG
19
77
1.33 (0.63–2.83)
162
78
1.64 (1.06–2.54)
1Only SNPs associated with NSCLC risk among either never smokers or ever smokers are displayed. 2Adjusted for age at diagnosis/interview, years of education, family history of lung cancer, history of COPD, adult aspirin use, and BMI. 3Adjusted for age at diagnosis/interview, smoking pack-year history, years of education, family history of lung cancer, history of COPD, adult aspirin use, and BMI.
